遺伝子導入によるがん熱中性子捕捉療法の適応拡大
Gene Transfer-applied Cancer Boron Neutron Capture Therapy

1999年2月　(February, 1999)
編集：三島豊
Edited by：Yutaka Mishima

目次/Contents

Ⅰ. 本研究の目的と研究の現況（ⅷ）

Ⅱ. 研究発表

1. Current Clinical Paradigms in Melanoma BNCT-Leading to Cell Modulation Era Teamed with Passive and Active 10B-Biodelivery Systems/ Yutaka Mishima, Hirofumi Kondoh, Kazuo Yoshino and Junichi Hiratsuka  /p.1
2. Enhanced Melanogenesis Induced by Tyrosinase Gene-Transfer Increases Boron-Uptake and Killing Effect of Boron Neutron Capture Therapy for Amelanotic Melanoma / Tatsuya Tsuboi, Hirofumi Kondoh, Junichi Hiratsuka and Yutaka Mishima  /p.18
3. Melanoma and Nonmelanoma Neutron Capture Therapy Using Gene Therapy-Overview/ Yutaka Mishima  /p.26
4. In vivo Diagnosis of Human Malignant Melanoma with Positron Emission Tomography Using Specific Melanoma-seeking ¹⁸F-DOPA Analogue / Yutaka Mishima, Yoshio Imahori, Chihiro Honda, Junichi Hiratsuka, Satoshi Ueda. and Tatsuo Ido  /p.42
5. Neutron Capture Therapy Using ¹⁰B-BPA and Gd-DTPA in Combination for Hamster Melanoma/ Chihiro Honda, Yutaka Mishima, Junichi Hiratsuka, Nobutoshi Wadabayashi, Hiroshi Karashima and Masamitsu Ichihashi  /p.49
6. Pharmacokinetics of ¹⁰B-p-boronophenylalaninein Tumours, Skin and Blood of Melanoma Patients-A Study of Boron Neutron Capture Therapy for Malignant Melanoma / Hiroshi Fukuda, Chihiro Honda, Nobutoshi Wadabayashi, Tooru Kobayashi, Kazuo Yoshino, Junichi Hiratsuka, Jutaro Takahashi, Takashi Akaizawa, Yoshinao Abe, Masamitsu Ichihashi and Yutaka Mishima  /p.53
7. マウスmelanoma脳内移植モデルにおける¹⁰B-boronophenylalanine の腫瘍集積性 /穀内隆，玉木紀彦，今堀良夫，坪井達也，近藤浩文，三嶋豊
   Accumulation of ¹⁰B-boronophenylalanine in Intracerebral Implantation Model of Mouse Melanoma Cells / Takashi Kokunai, Norihiko Tamaki, Yoshio Imahori, Tatsuya Tsuboi, Hirofumi Kondoh and Yutaka Mishima  /p.75
8. A Novel Approach for in vivo Gene Delivery to Tumor Cells via Transferrin Receptor by Transferrin-Strepavidin-DNA Conjugate / Yasushi Sato-, Hiroshi Neda, Katunori Sasaki, Minoru Takahashi, Junki Fukaura, Shigeyuki Fujii, Yoshikazu Koshita, Naofumi Yamauchi, Junji Kato, Sumio Sakamaki and Yoshiro Niitsu  /p.81
9. A Big Gene Linked to Small Eyes Encodes Multiple Mitf Isoforms – Many Promoters Make Light Work/ Ken-ichi Yasumoto, Shintaro Amae, Tetsuo Udono, Nobuo Fuse, Kazuhisa Takeda and Shigeki Shibahara  /p.97
10. Role of Neurofibromin in Modulation of Expression of the Tyrosinase-related Protein 2 Gene/ Hiroyuki Suzuki, Kazuhiro Takahashi, Ken-ichi Yasumoto, Shintaro Amae, Miki Yoshizawa., Nobuo Fuse and Shigeki Shibahara  /p.105
11. Identification of a Novel Isoform of Microphthalmia-associated Transcription Factor That Is Enriched in Retinal Pigment Epithelium/ Shintaro Amae, Nobuo Fuse, Ken-ichi Yasumoto, Shigeru Sato, Ichiro Yaji.ma, Hiroaki Yamamoto, Tetsuo Udono, Yusuf K. Durlu, Makoto Tamai, Kazuhiro Takahashi and Shigeki Shibahara  /p.112
12. A Further Mechanism Study of Boron Accumulation to and Release from Melanoma with p-Boronophenylalanine / Kazuo Yoshino, Mamiko Kamijo, Mototetsu Kimura, Yutaka Mishima, Hirofumi Kondoh, Mitsutaka Kadota, Shusuke Ito, Kazumasa Wakamatsu and Hidetake Kakihana  /p.118
13. Capture of p-Boronophenylalanine in Malignant Melanoma Cells by Complex Formation with Melanin Monomers, DOPA, DBI and DHICA / Kazuo Yoshino, Yutaka Mishima, Mototetsu Kimura, Junichi Hiratsuka, Yoshihiro Mori, Shosuke Ito and Hidetake Kakihana  /p.124
14. Determination of Released Boric Acid in vivo after p-Boronophenylalanine Administration into Melanoma-bearing Subjects / Kazuo Yoshino, Ryoko Nakajima, Akira Takaoka, Yoshihiro Mori, Hidetake Kakihana, Yutaka Mishima and Masamitsu Ichihashi  /p.129
15. メラノーマヘの¹⁰B取込機構一¹⁰B-p-ボロノフェニルアラニンによる¹⁰Bのメラノーマ細胞への取り込みとその集積機構 /吉野和夫、三嶋豊、木村基哲、伊藤祥輔、本田千博
    Mechanism Study on¹⁰B-Accumulationin Melanoma Cells by ¹⁰B-p-Boronophenylalanine / Kazuo Yoshino, Yutaka Mishima, Mototetsu Kimura, Shosuke Ito and Chihiro Honda  /p.134
16. Selective Uptake of p-Boronophenylalanine Increases by Transfecting Tyrosinase Gene to Melanoma Cells / Junichi Hiratsuka, Hirofumi Kondoh, Tatsuya Tsuboi, Kazuo Yoshino, Yoshinari Imajo and Yutaka Mishima   /p.138
17. Tumor-killing Effect of BNCT after Administration of o-, m-and p-Boronophenylalanine / Junichi Hiratsuka, Kazuo Yoshino, Chihiro Honda, Yutaka Mishima and Masamitsu Ichihashi  /p.148
18. The Combined Effect of Boronophenylalanine and Borocaptate in Boron Neutron Capture Therapy for SCCVII Tumors in Mice / Koji Ono, Shin-ichiro Masunaga, Minoru Suzuki, Yuko Kinashi, Masao Takagaki and Mitsuhiko Akaboshi  /p.152
19. Effects of Electroporation on the Cell Killing by Boron Neutron Capture Therapy Using Borocaptate Sodium (¹⁰B-BSH) /Koji Ono, Yuko Kinashi, Shin-ichiro Masunaga, Minoru Suzuki and Masao Takagaki  /p.163
20. Boron Neutron Capture Therapy for Malignant Glioma at Kyoto/ University Reactor / Koji Ono, Satoshi Ueda, Yoshifumi Oda, Yoshinobu Nakagawa, Shinich Miyatake, Masao Takagaki, Masami Osawa and Tooru Kobayashi  /p.169
21. 新規のエマルジョン液滴融合法による中性子捕捉療法用キトサンナノパーティクルの調製とその評価/ 徳満宏之、市川秀喜、福森義信、平塚純一、櫻井良憲、古林徹 
    Preparation and Evaluation of Chitosan Nanoparticles for Neutron-Capture Therapy by a Novel Emulsion-Droplet Coalescence Technique / Hiroyuki Tokumitsu, Hideki Ichikawa, Yoshinobu Fukumori, Junichi Hiratsuka, Yoshinori Sakurai and Tooru Kobayashi  /p.176
22. レシチンおよびコーサーファクタントで安定化した中性子捕捉療法用エマルションの体内動態/ 平野薫，宮本雅仁、市川秀喜、福森義信
    Biodistribution of Emulsions Stabilized with Phosphatidylcholine-Surfactant Mixtures for Neutron-Capture Therapy / Kaoru Hirano, Masahito Miyamoto, Hideki Ichikawa and Yoshinobu Fukumori  /p.184