ホウ素熱中性子捕捉療法の適応拡大に関する研究
副題：単クローン抗体利用の10B集積，即発γ線による癌診断，L体単離による10B-BPAの薬効増強
Investigation for the Extended Application of Melanoma Boron Neutron Capture Therapy
開催日：1991年11月 (November, 1991)
編集：三島豊
Edited by： Yutaka Mishima
目次
Preface / Editor : Yutaka Mishima（Professor & Chairman, Department of Dermatology, Director, Special Institute of Cancer Neutron Capture Therapy, Kobe University School of Medicine）ⅵ
序文 / 三島豊（神戸大学医学部皮膚科学講座 教授 熟中性子捕捉癌療法特別研究施設長）ⅶ
I. 本研究の目的と現況-viii
II. 研究発表
1. Treatment of Malignant Melanoma by Single Thermal Neutron/ Capture Therapy with Melanoma-Seeking 10B-compound（Yutaka Mishima, Chihiro Honda, Masamitsu Ichihashi, Hidefumi Obara, Junichi Hiratsuka, Hiroshi Fukuda, Hiroshi Karashima, Tooru Kobayashi, Keiji Kanda and Kazuo Yoshino） /p.1
2. Treatment of Malignant Melanoma by Selective Thermal Neutron Capture Therapy Using Melanoma-Seeking Compound/ （Yutaka Mishima, Masamitsu Ichihashi, Masayuki Tsuji, Susumu Hatta, Masato Ueda, Chihiro Honda and Tatsuo Suzuki） /p.3
3. メラノーマ新放射縁療法－ヒト謳性黒色厘の熱中性子捕捉療法を中心に－ / 三島豊，本田千博，市橋正光
Melanoma New-Radiotherapy :Thermal Neutron Capture Therapy of Malignant Melanoma / Yutaka Mishima, Chihiro Honda and Masamitsu Ichihashi /p.8
4. Further In Vitro Radiobiological Analysis on 10B-BPA BNCT of Malignant Melanoma : Correlation of Determined 10B-Content and Cell Killing Effect/ Masamitsu Ichihashi, Masahiro Shiono, Keizo Yamamura, Atsuko Komura, Yutaka Mishima, Kazuo Yoshino, Tooru Kobayashi, Keiji Kanda, Hiroshi Fukuda and Yoshiki Hori /p.21
5. 4-Borono-2-[18F]Fluoro-D, L-Phenylalanine as a Target Compound/ for Boron Neutron Capture Therapy : Tumor Imaging Potential with Positron Emission Tomography / Kiichi Ishiwata, Tatsuo Ido, Mieko Kawamura, Kazuo Kubota, Masamitsu Ichihashi and Yutaka Mishima /p.25
6. 4-Borono-2-[18F]Fluoro-D, L-Phenylalanine : A Possible Tracer for Melanoma Diagnosis with PET/ Kiichi Ishiwata, Tatsuo Ido, Chihiro Honda, Mieko Kawamura, Masamitsu Ichihashi and Yutaka Mishima /p.31
7. Synthesis and Radiation Dosimetry of 4-Borono-2-[18F]Fluoro-D,L-Phenylalanine : A Target Compound for PET and Boron Neutron Capture Therapy/ Kiichi Ishiwata, Tatsuo Ido, Alvaro A. Mejia, Masamitsu Ichihashi and Yutaka Mishima /p.48
8. Antigen Dynamics in Melanocytic and Nevocytic Melanoma / Oncogenesis : Anti-Ganglioside and Anti-ras p21 Antibodies as Markers of Tumor Progression/ Keizo Yamamura and Yutaka Mishima /p.52
9. Different Fine Binding Specificities of Monoclonal Antibodies to Disialoganglioside GD2 / Tadashi Tai, Ikuo Kawashima, Nobuhiko Tada and Kazuo Dairiki /p.61
10. Mouse Monoclonal Antibodies Detecting Disialogangliosides on Mouse and Human T Lymphomas / Ikuo Kawashima, Nobuhiko Tada, Shuji Ikegami, Shuji Nakamura, Ryuzo Ueda and Tadashi Tai /p.67
11. 抗ガングリオシド(GD2)モノクローナル抗体投与によるT細胞白血病に対する抗腫瘍効果 / 多田伸彦、田井直、上田龍三、黒津隆宏、藤森隆夫
Experimental Serotherapy of Mouse T-cell Leukemia with Anti-Ganglioside (GD2)Monoclonal Antibodies / Nobuhiko Tada, Tadasi Tai, Ryuzo Ueda, Takahiro Kurotsu and Takao Fujimori /p.75
12. Characterization of Mouse Melanoma Associated Antigen and Genomic Cloning/ Masaru Taniguchi, Kazuaki Takahashi, Yoshio Hirabayashi, Masatoshi Tagawa, Tohru Sakamoto, Akira Okitsu and Nobumi Kusakabe /p.82
13. Isolation of Genomic DNA Controlling Mouse Melanoma Antigen Defined by Monoclonal Antibody / Akira Okitsu, Masatoshi Tagawa, Yoshio Tamura, Masamoto Kanno, Hisahiro Matsubara, Toshihiro Ito, Kenji Imai, Kazuhiro Shigemoto, Ikuro Nakamura, Haruhiko Koseki, Yun-Fai Lau and Masaru Taniguchi /p.90
14. Characterization of a Melanoma Antigen with a Mouse-specific Epitope Recognized by a Monoclonal Antibody with Antimetastatic Ability / Hisako Sakiyama, Eiki Matsushita, Ichiro Kuwahara, Mutsumi Nozue, Toshiko Takahashi and Masaru Taniguchi /p.98
15. Melanoma Antigen and Transforming Gene/ Masatoshi Tagawa, Tohru Sakamoto, Akira Okitsu, Yoshio Tamura, Kenji Imai, Hisahiro Matsubara and Masaru Taniguchi /p.104
16. Genomic DNA with Transformation-Related Activity and Melanoma Antigen Expression / Masatoshi Tagawa, Tohru Sakamoto, Yoshio Tamura, Kenji Imai, Toshihiro Ito, Hisahiro Matsubara, Masamoto Kanno, Kazuhiro Shigemoto, Haruhiko Koseki and Masaru Taniguchi /p.113
17. Density of GM3 with Normal Primary Structure Determines Mouse Melanoma Antigenicity : a New Concept of Tumor Antigen / Yoshitada Harada, Minoru Sakatsume, Gustavo A. Nores, Sen-itiroh Hakomori and Masaru Taniguchi /p.118
18. Properties of Mouse Melanoma Antigen and Its Secretion Mechanism from the Cell Surface/ Ichiro Kuwabara, Masatoshi Tagawa, Yoshitada Harada, Toshihiro Ito and Masaru Taniguchi /p.123
19. Induction of Mouse Anti-melanoma Cytotoxic and Suppressor T Cells in vitro by an Artificial Antigen, GM3-lactone / Yoshitada Harada, Minoru Sakatsume and Masaru Taniguchi /p.130
20. Cross-Species Melanoma Antigen/ Masaru Taniguchi, Ichiro Kuwabara, Yoshitada Harada, Minoru Sakazurne and Kumeo Ono /p.135
21. Mouse Melanoma Antigens and Autoreactive T Cell Responses / Akihiro Kurosu, Minoru Sakatsume, Ichiro Kuwabara, Masato Kantake, Harhiko Koseki and Masaru Taniguchi /p.144
22. モノ、ジ及びトリ（モノカルポキシアルキル）アンモニオーウンデカ ヒドロドデカポレート(-1) /中川俊夫．三島豊
Mono-, Di-, and Tri-(Monocarboxyalkyl)ammonio-undecahydrododecaborates(-1) / Toshia Nakagawa and Yutaka Mishima /p.155
23. Thermal Neutron Capture Therapy of Malignant Melanoma Using 10B-Monoclonal Antibodies : In Vitro and In vivo Analysis / Atsuko Komura, Toshio Nakagawa Masamitsu Ichihashi and Yutaka Mishima /p.175
24. Comparative Analytical Studies on Selective Boron Accumulation in Hamster Melanoma by Different Administration Routes of 10B1-BPA for Neutron Capture Therapy / Chihiro Honda, Masahiro Shiono, Nobutoshi Wadabayashi, Susumu Hatta, Masamitsu Ichihashi, Yutaka Mishima, Tooru Kobayashi, Keiji Kanda, Kazuo Yoshino and Yoshiki Hori /p.192
25. In Situ Detection of Cutaneous Melanoma by Prompt Gamma-Ray Spectrometry Using Melanoma-Seeking 10B-Dopa Analogue/ Chihiro Honda, Yutaka Mishima, Masamitsu Ichihashi and Susumu Hatta /p.200
26. Improvement of Calculational Technique on Flux Distributions in a Water Phantom Caused by Narrow Thermal Neutron Beam for Neutron Capture Therapy / Masayuki Ono, Tooru Kobayashi and Keiji Kanda /p.209
27. Reevaluation of Thermal Neutron Field of the KUR Heavy Water Facility for Biomedical Uses : Optimization of Bismuth, Heavy Water and Graphite Layers/ Shusuke Fujihara, Tooru Kobayashi and Keiji Kanda /p.216
28. Boron-10 Quantitative Analysis of Neutron Capture Therapy on Malignant Melanoma by Spectrophotometric a-Track Reading / Masao Takagaki and Yutaka Mishima /p.227
29. Optical Resolution of 10B-p-Boronophenylalanine for Neutron Capture Therapy/ Kazuo Yoshino, Takanobu Maruyama, Satomi Mieda, Motoko Ogawa, Ikuko Umeda, Yoshihiro Mori, Yutaka Mishima and Masamitsu Ichihashi /p.232
30. Increased Boron Uptake by Hamster Melanoma Using L-Isomer B1-BPA for Neutron Capture Therapy / Chihiro Honda, Masahiro Shiono, Nobutoshi Wadabayashi, Masamitsu Ichihashi, Yutaka Mishima, Kazuo Yoshino, Tooru Kobayashi, Keiji Kanda, Yoshiki Hori and Hiroshi Karashirna /p.243
31. In Vivo Cellular Pharmacology on the Selective Affinity of 10B1-BPA for Malignant Melanoma /Masahiro Shiono, Takakazu Shibata, Chihiro Honda, Nobutoshi Wadabayashi, Masamitsu Ichihashi, Yoshiki Hori, Kazuo Yoshino and Yutaka Mishima /p.249
32. Rapid Spectrophotometric Determination of Trace Boron in Tissues/ for Boron Neutron Capture Therapy / Kazuo Yoshino, Chie Nishio, Eri Ubukata, Takanobu Maruyama, Yoshihiro Mori, Yutaka Mishima, Chihiro Honda, Masahiro Shiono, Nobutoshi Wadabayashi, Tooru Kobayashi and Keiji Kanda /p.253
33. 悪性黒色腫用10B 化合物ドーパポレートとp-ポロノフェニール/ アラニンの化学的挙動と中性子捕捉療法 /吉野和夫、森芳弘、垣花秀武
Chemical Behaviors of 10B dopa Borate and 10B-p-Boronophenylalanine for Boron Neutron Capture Therapy / Kazuo Yoshino, Yoshihiro Mori and Hidetake Kakihana /p.259
34. 10B化合物(BPA 関連）の構造とその熱中性子捕捉療法との関連/ 堀越秀彦、向田政男、垣花秀武、吉野和夫、森芳弘
Relationship between Structures of BPA-related 10B-compoundsand Their Uses in Thermal Neutron Capture Therapy / Hidehiko Horikoshi, Masao Mukaida, Hidetake Kakihana, Kazuo Yoshino and Yoshihiro Mori /p.269
35. Acute Toxicity of nB-Paraboronophenylalanine-Oral Administration / Kohtaro Taniyama, Akira Itoh and Chikako Tanaka /p.277
36. RBE of a Thermal Neutron Beam and the 10B(n, α) 7Li Reaction on Cultured B-16 Melanoma Cells / Hiroshi Fukuda,. Tooru Kobayashi, Taiju Matsuzawa, Keiji Kanda, Masamitsu Ichihashi and Yutaka Mishima /p.280
37. 基礎面からみた腫瘍治癒一腫瘍幹編腿数の重要性について一/ 安薦興一、福田寛、荒居竜雄、中野隆史
Tumor Control-Significance of the Stem Cell Number / Koichi Ando, Hiroshi Fukuda, Tatsuo Arai and Takashi Nakano /p.289
38. Mathematical Analysis of the Survival of HeLa S3 Cells Following / Neutron Capture Radiation : Calculation of RBE by a Linear- Quadratic Model / Yowri Ujeno, Mitsuhiko Akaboshi, Hirotoshi Maki and Kenichi Kawai /p.293
39. The Radiation Biology of Boron Neutron Capture Therapy / Hiroshi Utsumi /p.299