ヒト黒色腫のメラニン代謝活性親和性B-10 化合物による選択的熱中性子捕捉療法
Selective Thermal Neutron Capture Therapy of Malignant Melanoma Using Melanogenesis-seeking 10B-compounds
1991年11月 (November, 1991)
編集：三島豊
Edited by： Yutaka Mishima
目次
Preface Editor : Yutaka Mishima Professor & Chairman, Department of Dermatology, Director, Special Institute of Cancer Neutron Capture Therapy, Kobe University School of Medicine/ v
序文エデイター：三島豊（神戸大学医学部皮膚科学講座教授 熱中性子捕捉癌療法特別研究施設長）ⅶ
Ⅰ. 本研究の目的と現況 ⅶ
Ⅱ. 研究発表
1. Advances in the Control of Human Cutaneous Primary and Metastatic Melanoma by Thermal Neutron Capture Therapy /Yutaka Mishima, Masamitsu Ichihashi, Chihiro Honda, Masahiro Shiono, Toshio Nakagawa, Hidefumi Ohara, Junji Shirakawa, Junichi Hiratsuka, Keiji Kanda, Tooru Kobayashi, Tetsuya Nozaki, Otohiko Aizawa, Tadashi Sato, Hiroshi Karashima, Kazuo Yoshino and Hiroshi Fukuda /p.1
2. 10B1-BPA Administration to Human Melanoma Patients Boron Analytical Studies for Neutron Capture Therapy / Chihiro Honda, Masahiro Shiono, Nobutoshi Wadabayashi, Susumu Hatta, Masamitsu Ichihashi, Yutaka Mishima, Kazuo Yoshino, Tooru Kobayashi, Keiji Kanda and Yoshiki Hori /p.7
3. First Human Clinical Trial of Melanoma Neutron Capture : Diagnosis and Therapy / Yutaka Mishima, Masamitsu Ichihashi, Susumu Hatta, Chihiro Honda, Keizo Yamamura, Toshio Nakagawa, Hidefumi Obara, Junji Shirakawa, Junichi Hiratsuka, Kohtaro Taniyama, Chikako Tanaka, Keiji Kanda, Tooru Kobayashi, Takashi Sato, Masahiro R. Ishida, Yowri Ujeno, Masaji Takahashi, Mitsuyuki Abe, Tetsuya Nozaki, Otohiko Aizawa, Tetsuo Matsumoto, Tadashi Sato, Hiroshi Karashima, Kazuo Yoshino and Hiroshi Fukuda /p.19
4. Selective Thermal Neutron Capture Therapy and Diagnosis of Malignant Melanoma : From Basic Studies to First Clinical Treatment / Yutaka Mishima, Masamitsu Ichihashi, Susumu Hatta, Chihiro Honda, Akihiro Sasase, Keizo Yamamura, Keiji Kanda, Tooru Kobayashi and Hiroshi Fukuda /p.23
5. 悪性メラノーマ/ 三島豊、本田千博
Malignant Melanoma/ Yutaka Mishima and Chihiro Honda /p.33
6. ヒト悪性黒色腫の熱中性子捕捉療法による治癒/ 三島豊、本田千博、市橋正光、塩野正博
Cure of Human Malignant Melanoma by Thermal Neutron Capture Therapy /Yutaka Mishima, Chihiro Honda, Masamitsu Ichihashi and Masahiro Shiono /p.40
7. 悪性黒色腫の熱中性子捕捉療法/ 市橋正光、三島豊
Thermal Neutron Capture Therapy for Malignant Melanoma/ Masamitsu Ichihashi and Yutaka Mishima /p.46
8. In Vitro Evaluation of 10B-BPA for Melanoma at MOAT A-Joint Work between Japan and Australia BNCT Research Teams / Masamitsu Ichihashi, Hiroshi Fukuda, J. Keith Brown, Max H. Mountford, Barry J. Allen, J. Gerald Wilson and Yutaka Mishima /p.53
9. Improved Bioavailability of Para-Boronophenylalanine by Cyclodextrin Complexation / Hisakatsu Hatanaka, Fusao Komada, Masahiro Shiono, Yutaka Mishima and Katsuhiko Okumura /p.57
10. Relation between Tolerance Dose of Skin and Boron-10 Concentration in Neutron Capture Therapy for Cutaneous Melanoma / Tooru Kobayashi, Keiji Kanda, Yowri Ujeno, Hiroshi Fukuda, Koichi Ando, Yutaka Mishima, Masamitsu Ichihashi and Junichi Hiratsuka /p.68
11. The Relative Biological Effectiveness of 10B-Neutron Capture Therapy for Early Skin Reaction in the Hamster / Junichi Hiratsuka, Hiroshi Fukuda, Tooru Kobayashi, Hiroshi Karashima, Kazuo Yoshino, Yoshinari Imajo and Yutaka Mishima /p.72
12. In Situ Measurement on 10B Concentrations and Absorbed Dose/ Estimations in Human Malignant Melanoma Treated by BNCT / Tooru Kobayashi, Keiji Kanda and Yutaka Mishima /p.78
13. Measurement and Analysis on Neutron Flux Distributions in a Heavy Water Phantom Using the KUR Neutron Guide Tube for BNCT / Tooru Kobayashi, Masayuki Ono and Keiji Kanda /p.81
14. Effective Thermal Neutron Collimation for Neutron Capture Therapy Using Neutron Absorption and Scattering Reactions / Tooru Kobayashi, Shusuke Fujihara and Keiji Kanda /p.84
15. 京大炉における原子炉医療に関する治療照射システム/ 古林徹、神田啓治、上野陽里、石田政弘
Irradiation System for Boron Neutron Capture Therapy in the KUR / Tooru Kobayashi, Keiji Kanda, Yowri Ujeno and Masahiro R. Ishida /p.88
16. 中性子捕捉療法における効果的な熱中性子コリメーションー熱中性子の散乱体と吸収体の有効利用一/ 古林徹，神田啓治，藤原秀介
Effective Thermal Neutron Collimation for Neutron Capture Therapy : Usage of Neutron Scattering and Absorbing Materials/ Tooru Kobayashi, Keiji Kanda and Shusuke Fujihara /p.94
17. Biomedical Irradiation System for Boron Neutron Capture. Therapy at the Kyoto University Reactor / Tooru Kobayashi, Keiji Kanda, Yowri Ujeno and Masahiro R. Ishida /p.102
18. ほう素中性子捕捉療法における吸収線量評価よりみた治療照射条件/ －表在する謳性黒色麗に対する検討一/ 古林徹、神田啓治、上野陽里、福田寛、安藤興ー、平塚純一、三島豊、市橋正光
Irradiation Conditions Based on Absorbed Dose Estimation in Boron Neutron Capture Therapy for Superficially Located Malignant Melanoma / Tooru Kobayashi, Keiji Kanda, Yowri Ujerio, Hiroshi Fukuda, Koichi Ando, Junichi Hiratsuka, Yutaka Mishima and Masamitsu Ichihashi /p.121
19. 京大原子炉における医療照射経験－線量の測定およびその評価からみた照射技術的側面－ /古林徹、神田啓治、佐藤孝司、小野光一、秋吉恒和、海老沢徹、田崎誠司、上野陽里、芥田敬三、畠中坦、三島豊、織田祥史
Clinical Experiences for Neutron Capture Therapy Using the KUR : Technical Aspects Related to Thermal Neutron Irradiation and Its Dose Estimation /Tooru Kobayashi, Keiji Kanda, Takashi Sato, Koichi Ono, Tunekazu Akiyoshi, Toru Ebisawa, Seiji Tasaki, Yowri Ujeno, Keizo Akuta, Hiroshi Hatanaka, Yutaka Mishima and Yoshifumi Oda /p.133
20. p-Boronophenylalanine-Saccharide Complexes for Boron Neutron Capture Therapy/ Kazuo Yoshino, Yasuhiko Kinoshita, Yoshihiro Mori, Hidetake Kakihana and Yutaka Mishima /p.141
21. Improvement of Solubility of p-Boronophenylalanine by Complex Formation with Monosaccharides / Kazuo Yoshino, Akio Suzuki, Yosihiro Mori, Hidetake Kakihana, Chihiro Honda, Yutaka Mishima, Tooru Kobayashi and Keiji Kanda /p.145
22. Tolerance Limits of the Normal Skin Treated by a Single Thermal Neutron Capture Therapy / Hiroshi Fukuda, Koichi Ando, Chihiro Honda, Masamitsu Ichihashi, Yutaka Mishima, Junichi Hiratsuka, Tooru Kobayashi and Keiji Kanda /p.148
23. 熱中性子捕捉治療による吸収縁量の評価上の問題点/ 福田寛、安藤興一、古林徹、神田啓治、市橋正光、三島豊
Estimation of Absorbed Dose by Thermal Neutron Capture Therapy : Theoretical Basis and Problems / Hiroshi Fukuda, Koichi Ando, Tooru Kobayashi, Keiji Kanda, Masamitsu Ichihashi and Yutaka Mishima /p.151
24. 熱中性子捕捉療法における理論的予想反応と臨床反応の比較一抗腫瘍効果と皮膚反応について一 / 平塚純一、古林徹、神田啓治、福田寛、辛嶋博、吉野和夫、本田千博、市橋正光、三島豊
Comparison of Clinical Response with Calculated Response on Human Melanoma Treated by BNCT :Tumor Effect and Skin Reaction/ Junichi Hiratsuka, Tooru Kobayashi, Keiji Kanda, Hiroshi Fukuda, Hiroshi Karashima, Kazuo Yoshino, Chihiro Honda, Masamitsu Ichihashi and Yutaka Mishima /p.154
25. Two Methods of Anesthetic Management for Neutron Capture Therapy Summary of 8 Cases / Junji Shirakawa, Hidefumi Obara, Chihiro Honda and Yutaka Mishima /p.163
26. 悪性黒色腫のMRI診断に闘する実験的並びに臨床的研究 －ハムスター黒色腫におけるMR像と病理像との対比と臨床例への応用－ /青木理、河野通雄、三島豊
MR Imaging and Pathologic Correlation on Hamster Malignant Melanoma and Clinical Application/ Osamu Aoki, Michie Kono and Yutaka Mishima /p.167
27. BNCT Clinical Experiences in KURRI for 1990 and 1991/ Yowri Ujeno, Keizo Akuta and Yoshifumi Oda /p.183
28. 速中性子線による悪性黒色腫の治療成績/ 恒元博，森田新六
Results of Treatment with Fast Neutron for Malignant Melanoma/ Hiroshi Tsunemoto and Shinroku Morita /p.185