京都大学複合原子力科学研究所 学術出版委員会

KURRI-TR-374

ヒト悪性黒色腫全5射型のそれぞれに対応した 最適熱中性子捕捉療法の確立
Establishment of Optimal Thermal Neutron Capture Therapy  for 5 Types of Human Malignant Melanoma

開催日：1993年3月　(March, 1993)
編集：三島豊
Edited by： Yutaka Misima

目次/Contents

Preface / Editor : Yutaka Mishima / Honorary Professor、Kobe University School of Medicine Director, Kobe Kaisei Hospital Research Institute Chief、Dermatology Department Director、Mishima Institute for Dermatological Research（vii）

序文 / エディター：三島豊（神戸大学医学部名誉教授、神戸海星病院研究所長・皮膚科部長、三嶋皮膚科学研究所長）(ⅸ）

Ⅰ. 本研究の目的と研究の現況．（ⅹ）

Ⅱ. 研究発表

  1. In Vivo Diagnosis of Human Malignant Melanoma Using Specific Melanoma-Seeking 18F-Compound with Positron Emission Tomography / Yutaka Mishima, Yoshio Imahori、ChihiroHonda, Satoshi Ueda and Tatsuo Ido  /p.1
  2. Selective Melanoma Thermal Neutron Capture Therapy for Lymph Node Metastases / Yutaka Mishima, Chihiro Honda, Masarnitsu Ichihashi, Masahiro Shiono, Nobutoshi Wadabayashi、Hidefurni Obara, Junichi Hiratsuka, Hiroshi Fukuda, Hiroshi Karashima, Keiji Kanda, Tooru Kobayashi and Kazuo Yoshino  /p.11
  3. Chairman’s Summary: Malignant Melanoma / Yutaka Mishima  /p.17
  4. Treatment of Metastatic Melanoma by Neutron Capture Therapy/ Yutaka Mishima、Masarnitsu Ichihashi, Chihiro Honda、Masahiro Shiono, Toshia Nakagawa, Hidefurni Obara, Junji Shirakawa, Junichi Hiratsuka, Keiji Kanda, Tooru Kobayashi, Tetsuya Nozaki, Otohiko Aizawa, Kazuo Yoshino and Hiroshi Fukuda  /p.1
  5. 多段階癌化による悪性黒色腫の発生/三嶋豊  /p.25
    Ontogeny of Human Malignant Melanoma through Multi-Step Carcinogenesis /Yutaka Mishima
  6. 悪性黒色腫の選択的熱中性子捕捉療法· ーヒト症例の治療一 / 三嶋豊，本田千博，塩野正博，和田林展年，市橋正光，尾原秀史，福田寛， 平塚純一，辛嶋博，神田啓治，古林徹  /p.37
    Selective Thermal Neutron Capture Therapy of Malignant Melanoma: Treatment of Human Cases / Yutaka Mishima, Chihiro Honda, Masahiro Shiono, Nobutoshi Wadabayashi, Masamitsu Ichihashi, Hidefumi Obara、Hiroshi Fukuda, Junichi Hiratsuka、HiroshiKarashima, Keiji Kanda and Tooru Kobayashi
  7. 悪性黒色腫の特異的代謝活性による熱中性子捕捉療法 /三嶋豊，市橋正光，本田千博，塩野正博，小村敦子，和田林展年，中川俊夫  /p.49
    Selective Thermal Nuetron Capture Therapy of Malignant Melanoma Using Its  Specific Metablic Activities / Yutaka Mishima, Masamitsu Ichihashi, Chihiro Honda, Masahiro Shiono, Atsuko Komura, Nobutoshi Wadabayashi and Toshia Nakagawa
  8. 8. Tissue Distribution of Para-Boronophenylalanine Administered Orally as a Cyclodextrin Inclusion Complex to Melanoma-Bearing Hamsters/ Hisakatsu Hatanaka, Fusao Komada, Masahiro Shiono, Yutaka Mishima and Katsuhiko Okumura  /p.56
  9. 9. ホウ素熱中性子捕捉療法のための10B化合物の腫瘍細胞親和性に関する研究-10B1-Paraboronophenylalanineの悪性黒色腫細胞特異的集積性の機序について一/ 塩野正博，芝田孝一，市橋正光，三嶋豊  /p.59
    The Mechanism of the Selective Affinity of 10B1-Paraboronophenylalanine for Malignant Melanoma / Masahiro Shiono, Takakazu Shibata, Masamitsu Ichihashi and Yutaka Mishima
  10. Deuteriation Trials for Neutron Capture Therapy of Deep-Seated Melanoma Lesions / Chihiro Honda, Masahiro Shiono, Nobutoshi Wadabayashi, Masamitsu Ichihashi, Yutaka Mishima, Kazuo Yoshino, Tooru Kobayashi、KeijiKanda and Hiroshi Karashima  /p.66
  11. Experiences of BNCT Using the KUR / Keiji Kanda, Tooru Kobayashi, Keizo Akuta and Koji Ono  /p.70
  12. Procedures for the Medical Application of Research Reactors / Keiji Kanda  /p.75
  13. 医療用原子炉/ 神田啓治，三嶋豊  /p.79
    Medical Reactor / Keiji Kanda and Yutaka Mishirna
  14. Study on Remodeling the Heavy Water Facility of the Kyoto University Reactor for Neutron Capture Therapy from the Concept of Neutron Energy Spectrum Control / Tooru Kobayashi、YoshinoriSakurai and Keiji Kanda  /p.87
  15. Analytical Dose Calculation in Cell Nucleus from Spherical 10B Containing Region and a Concept of RBE for Neutron Capture Therapy/ Tooru Kobayashi and Keiji Kanda  /p.91
  16. 医学物理学からみた中性子捕捉療法の現状と将来/古林徹，神田啓治  /p.95
    The Status and the Future of Medical Physics for Neutron Capture Therapy/ Tooru Kobayashi and Keiji Kanda
  17. 医療照射を主目的にした重水熱中性子設備改造検討/ 古林徹，桜井良憲，神田啓治  /p.98
    Study on Remodeling of the Heavy Water Facility of the Kyoto University Reactor Mainly from the Viewpoint of Neutron Capture Therapy / Tooru Kobayashi, Yoshinori Sakurai and Keiji Kanda
  18. BNCT における生体内深部での熱中性子線量率改善の計算及び実験/ による検討 / 桜井良憲，古林徹，小野光一， 佐藤孝司， 神田啓治  /p.106
    Improvement of Thermal Neutron Fluence at the Deeper Part in Tissue for BNCT: Simulation Calculation and Phantom Experiment / Yoshinori Sakurai, Tooru Kobayashi、Koichi Ono, Takashi Sato and Keiji Kanda
  19. Improvement of Thermal Neutron Fluence for BNCT Treatment of Deep-Seated Tumors : Simulation Calculation and Phantom Experiments/ Yoshinori Sakurai、Tooru Kobayashi, Koichi Ono, Takashi Sato and Keiji Kanda   /p.114
  20. 中性子捕捉療法における生体表面近傍での熱中性子線量測定およびその評価並びに生体内深部での熱中性子線量分布の改善に関する研究/ 桜井良憲，古林徹，神田啓治  /p.119
    A Study on Measurement and Estimation of Thermal Neutron Dose near the Surface of Human Body, and Improvement of Thermal-Neutron Dose Distribution at the Deeper Part for Neutron Capture Therapy / Yoshinori Sakurai, Tooru Kobayashi and Keiji Kanda
  21. 熱中性子束測定における生体表面近傍での金線および金箔の自己遮蔽因子の検討 /桜井良憲，景平克志，古林徹，神田啓治  /p.139
    A Study on Self-Shielding Factor near the Surface of Human Body Using Gold Wire and Foil for Thermal Neutron Flux Measurement / Yoshinori Sakurai, Katsushi Kagehira, Tooru Kobayashi and Keiji Kanda
  22. Reevaluation of Thermal Neutron Field of the KUR Heavy Water Facility for Biomedical Uses : Optimization of Bismuth, Heavy Water and Graphite Layers / Yoshinori Sakurai, Shusuke Fujihara, Tooru Kobayashi and Keiji Kanda  /p.147
  23. Analysis for Remodeling of the KUR Heavy Water Facility for Biomedical Uses : Shutter System for Continuous Use of the Facility under 5MW Operation / Yoshinori Sakurai、Tooru Kobayashi and Keiji Kanda  /p.152
  24. Evaluation of Neutron Irradiation Fields for BNCT by Using / Otohiko Aizawa  /p.163
  25. Determination of p-Boronophenylalanine in Biological Tissues with High Performance Liquid Chromatography/ Kazuo Yoshino, Tomaro Takasoh, Hisakatsu Hatanaka, Fusao Komada、Katsuhiko Okumura, Yutaka Mishima, Chihiro Honda and Yoshihiro Mori  /p.168
  26. Relation between Structures of p-Boronophenylalanine Related Compounds and Their Usefulness for Boron Neutron Capture Therapy/ Hidetake Kakihana, Kazuo Yoshino and Yoshihiro Mori  /p.175
  27. Capture of p-Boronophenylalanine by Melanin-Related Compounds: Complex Formation of p-Boronophenylalanine with L-Dopa / Kazuo Yoshino、Takanobu Maruyama, Yoshihiro Mori, Hidetake Kakihana and Yutaka Mishima  /p.179
  28. Proposed Mechanism of Capture and Release of p-Boronophenyl-alanine through Melanoma Cells : Chemical Behaviour of p-Boronophenylalanine- Fructose Complex in L-Dopa Solution / Kazuo Yoshino, Hidetake Kakihana、YoshihiroMori, Naruyuki Torii, Hiroaki Takahashi and Yutaka Mishima  /p.183
  29. Synthesis of o-and m-Boronophenylalanine / Kazuo Yoshino、Takanobu Maruyama, Hiroaki Takahashi, Yoshihiro Mori、Hidetake Kakihana, Yutaka Mishima, Masamitsu Ichihashi, Chihiro Honda and Masahiro Shiono  /p.187
  30. A New Water-Soluble p-Boronophenylalanine Derivative for Neutron Capture Therapy / Hisao Nemoto, Satoshi Iwamoto、Hiroyuki Nakamura and Yoshinori Yamamoto  /p.191
  31. Preliminary Studies on the Preparation of Boronated Monoclonal Antibodies Intended for Neutron Capture Therapy / Toshia Nakagawa, Yutaka Mishima, Kazuhito Hayashibe and Masamitsu Ichihashi  /p.191
  32. Optimization of Neutron Fluence and Timing of Irradiation for the Treatment of Malignant Melanoma by Boron Neutron Capture Therapy Using 10B-Paraboronophenylalanine / Hiroshi Fukuda, Junichi Hiratsuka, Chihiro Honda, Tooru kobayashi, Kazuo Yoshino, Yoshinao Abe, Jutaro Takahashi, Masahiro Shiono, Hiroshi Karashima, Keiji Kanda, Masamitsu Ichihashi and Yutaka Mishima  /p.212
  33. 中性子捕捉療法の現状(3)-＊ホウ素中性子捕捉治療の現状と問題点/ 福田寛  /p.221
    Present Status of Neutron Capture Therapy of Cancer (3) : Present Status and Problems of Boron Neutron Capture Therapy of Malignant Melanoma / Hiroshi Fukuda /p.221
  34. 放射線療法－黒色腫退縮効果－福田寛、恒元博  /p.223
    Radiotherapy of Malignant Melanoma :Radiosensitivity and Local Control /Hiroshi Fukuda and Hiroshi Tsunemoto
  35. Thermal Neutron Capture Therapy Using 10B1-BPA: Inducement of Marked Lethal Effect on Melanoma Cells Irrespective of X-ray / Sensitivity / Masamitsu Ichihashi, Hiroshi Utsumi, Hidekazu Tsukamoto, Yutaka Mishima and Tooru Kobayashi  /p.22
  36. 熱中性子捕捉療法を施行した悪性黒色腫症例の吸収線量分布と局所効果 /平塚純一，福田寛，古林徹，神田啓治，市橋正光，三嶋豊  /p.235
    The Local Response and the Absorbed Dose in a Human Melanoma Treated by Neutron Capture Therapy / Junichi Hiratsuka, Hiroshi Fukuda, Tooru Kobayashi, Keiji Kanda, Masamitsu Ichihashi and Yutaka Mishima
  37. 悪性黒色腫に対する熱中性子捕捉療法の治療効果比 / 平塚純一，福田寛，古林徹，三嶋豊  /p.245
    Therapeutic Gain Factor of Thermal Neutron Capture Therapy of Malignant Melanoma / Junichi Hiratsuka, Hiroshi Fukuda, Tooru Kobayashi and Yutaka Mishima
  38. A Unique in Vivo Assessment of 4-[10B] borono-L-Phenylalanine in Tumor Tissues for Boron Neutron Capture Therapy of Malignant Melanomas Using Positron Emission Tomography and 4-Borono-2-[18F] Fluoro-L-Phenylalanine/ Kiichi Ishiwata, Masahiro Shiono, Kazuo Kubota, Kazuo Yoshino, Jun Hatazawa, Tatsuo Ido, Chihiro Honda, Masamitsu Ichihashi and Yutaka Mishima  /p.251
  39. 18F-1°B-L-BPAによる悪性黒色腫の画像化ーポジトロンCTによる生化学的評価とBNCTへの応用一 /今堀良夫，三嶋豊，本田千博，上田聖，堀井均，脇田員男，藤井亮，井戸達雄  /p.261
    Imaging and Metabolic Evaluation of Malignant Melanoma by Positron Emission Tomography using 18F-10B-L-BPA / Yoshio Imahori, Yutaka Mishima, Chihiro Honda, Satoshi Ueda, Hitoshi Horii, Kazuo Wakita, Ryou Fujii and Tatsuo Ido