転移性ならびに深達性ヒト悪性黒色腫の選択的熱中性子捕捉療法の樹立
Further Development of Thermal Neutron Capture Therapy for Metastatic and Deeply-Invasive Human Malignant Melanoma

1995年3月　(March, 1995)
編集：三島豊
Edited by：Yutaka Mishima

目次 / Contents

1. Selective Thermal Neutron Capture Therapy of Cancer Cells Using their Specific Metabolic Activities-Melanoma as Prototype/ Yutaka Mishima  /p.1
2. Boron Analytical Studies on ¹⁰B₁-BPA Administration for Neutron Capture Therapy of Malignant Melanoma/ Chihiro Honda, Nobutoshi Wadabayashi, Kazuo Yoshino, Junichi Hiratsuka, Hiroshi Karashima, Tooru Kobayashi, Hiroshi Fukuda, Masamitsu Ichihashi and Yutaka Mishima  /p.21
3. ¹⁰B₁-BPA Administration to Melanoma Patients for Neutron Capture Therapy (II)-from Nov.,1991 to Dec.,1994-/ Chihiro Honda, Nobutoshi Wadabayashi, Masamitsu Ichihashi, Yutaka Mishima, Kazuo Yoshino, Junichi Hiratsuka, Hiroshi Karashima, Hiroshi Fukuda and Tooru Kobayashi  /p.26
4. Two Cases of Primary Malignant Melanoma Treated by Selective Melanoma Thermal Neutron Capture Therapy / Kazumi Watanabe, Kaoru Ito, Yasuyuki Kaneko, Sumiko Satake, Satoshi Yamada, Hideo Yamaguchi, Tatsuya Takenouchi, Masaaki Ito and Yutaka Mishima  /p.31
5. Selective Boron Accumulation in Human Ocular Melanoma vs Surrounding Eye Components after ¹⁰B₁-p-Boronophenylalanine Administration. Prerequisite for Clinical Trial of Neutron-Capture Therapy/ Nobutoshi Wadabayashi, Chihiro Honda, Yutaka Mishima and Masamitsu Ichihashi  /p.37
6. Selective Detection of Brain Metastasis of Malignant Melanoma Using ¹⁸F-¹⁰B-L-Boronophenylalanine with Positron Emission Tomography/ Kazumasa Ehara, Norihiko Tamaki, Yoshie Hara, Yoshie Imahori, Hitoshi Horii, Satoshi Ueda, Junichi Hiratsuka and Yutaka Mishima  /p.43
7. Enhanced therapeutic Effect on Morine Melanoma and Angiosarcoma Cells by Boron Neutron Capture Therapy Using a Boronated Metalloporphyrin/ Yoshihiko Yamada, Ken-ichi Toda, Stephen B. Kahl and Masamitsu Ichihashi  /p.47
8. Physics of Boron Neutron Capture Therapy in Japan/ Keiji Kanda  /p.60
9. KUR重水設備の特徴とその利用法/ 神田啓治
   Characteristics of KUR Heavy Water Facility and Its Application/ Keiji Kanda   /p.68
10. 重水熱中性子設備改造の概念設計検討/ 古林徹、神田啓治、藤田薫顕、小野公二
    Conceptional Study on Remodeling of the Heavy Water Facility of the Kyoto University Reactor/ Tooru Kobayashi, Keiji Kanda, Yoshiaki Fujita and Koji Ono  /p.72
11. KUR重水熱中性子設備改造の原子炉工学面からの最適化設計検討/ 古林徹、桜井良憲、神田啓治、藤田薫顕
    A Design Study on the Remodeling of KUR-D₂O Thermal Neutron Facility for the Optimization from Reactor Physics and Engineerings / Tooru Kobayashi, Yoshinori Sakurai, Keiji Kanda and Yoshiaki Fujita  /p.81
12. The Utilization of Hyper-Thermal Neutrons for Neutron Capture·Therapy/ Yoshinori Sakurai, Tooru Kobayashi and Keiji Kanda  /p.89
13. ハイバー熱中性子照射場の設計検討/ 桜井良憲．古林徹，神田啓治
    A Feasibility Study on the Hyper-Thermal Neutron Irradiation Field for Neutron Capture Therapy/ Yoshinori Sakurai, Tooru Kobayashi and Keiji Kanda  /p.89
14. 中性子エネルギースペクトルシフターの設計検討/ 桜井良憲， 古林徹， 神田啓治， 藤田薫顕
    A Study on the Design of the Neutron Energy Spectrum Shifter/ Yoshinori Sakurai, Tooru Kobayashi, Keiji Kanda and Yoshiaki Fujita  /p.106
15. A Fundamental Study on Hyper-Thermal Neutrons for Neutron Capture therapy/ Yoshinori Sakurai, Tooru Kobayashi and Keiji Kanda  /p.115
16. Hyper-Thermal Neutron Irradiation Field for Neutron Capture therapy/ Yoshinori Sakurai, Tooru Kobayashi and Keiji Kanda  /p.126
17. Feasibility Study on Neutron Energy Spectrum Shifter in the KUR Heavy Water Facility for Neutron Capture therapy / Yoshinori Sakurai, Tooru Kobayashi, Keiji Kanda and Yoshiaki Fujita  /p.134
18. Design Study on Triangular-Hexagonal TRIGA Core for Epithermal Neutron Irradiation / Otohiko Aizawa  /p.152
19. Chemical Modeling for Boron Accumulation to and Release from Melanoma / Kazuo Yoshino, Yoshihiro Mori, Hidetake Kakihana, Hiroaki Takahashi, Yutaka Mishima and Masamitsu Ichihashi  /p.158
20. Chemical Properties of p-, m-, o-Boronophenylalanine / Kazuo Yoshino, Nobuya Watanabe, Hiroaki Takahashi, Shinji Watanabe, Yoshihiro Mori, Masamitsu Ichihashi, Hidetake Kakihana and Yutaka Mishima  /p.165
21. Examination of Stability of p-, m-, o-Boronophenylalanine in Blood with High Performance Liquid Chromatography/ Kazuo Yoshino, Naoko Koike, Yuko Kuroda, Yoshihiro Mori, Masamitsu Ichihashi, Hidetake Kakihana and Yutaka Mishima  /p.171
22. p-ボロノフェニルアラニンとメラニン代謝前駆体Lードーパとの錯形成および同錯体の酸化反応－p-ボロノフェニルアラニンによる悪性黒色腫への¹⁰Bの集積、減衰機構の化学的考察一/ 吉野和夫、高橋宏明、鳥居成幸、森芳弘、垣花秀武
    Complex Formation of p-Boronophenylalanine with L-DOPA (a Precursor of Melanine Metabolism) and Oxidation Reaction of the Analogs / Kazuo Yoshino, Hiroaki Takahasi, Naruyuki Torii, Yoshihiro Mori and Hidetake Kakihana  /p.177
23. 0—およびm—ポロノフェニルアラニンの合成と光学分割/高橋宏明，吉野和夫，丸山責信，森芳弘
    Synthesis of o-and m-Boronophenylalanine and their Optical Resolution/ Hiroaki Takahasi, Kazuo Yoshino, Takanobu Maruyama and Yoshihiro Mori  /p.184
24. Netropsin and Distamycin Analogues Bearing Ortho-Carborane / Yoshinori Yamamoto, Jianping Cai, Hiroyuki Nakamura, Naoki Sadayori and Hisao Nemoto  /p.188
25. Synthesis of a Water-Soluble o-Carborane Bearing Uracil Moiety via Palladium Catalyzed Reaction under Essentially Neutral Conditions/ Hisao Nemoto, Jianping Cai and Yoshinori Yamamoto  /p.194
26. BNCT of Malignant Melanoma-Radiobiological Analysis and Data Comparison with Conventional Radiotherapy/ Hiroshi Fukuda, Yutaka Mishima, Junichi Hiratsuka, Chihiro Honda, Nobutoshi Wadabayashi, Tooru Kobayashi, Kazuo Yoshino, Hiroshi Karashima, Jutaro Takahashi, Yoshinao Abe, Keiji Kanda and Masamitsu Ichihashi   /p.197
27. Pharmacokinetics of ¹⁰B-BPA in the Tumor, Skin and Blood in Melanoma Patients-A Study for Boron Neutron Capture Therapy of Malignant Melanoma/ Hiroshi Fukuda, Chihiro Honda, Nobutoshi Wadabayashi, Tooru Kobayashi, Kazuo Yoshino, Junichi Hiratsuka, Jutaro Takahashi, Masamitsu Ichihashi and Yutaka Mishima  /p.204
28. Early Clinical Trial and Related Research for the Development of BNCT / Hiroshi Fukuda and Yutaka Mishima  /p.210
29. Boron Neutron Capture Therapy of Malignant Melanoma Using ¹⁰B-Paraboronophenylalanine with Special Reference to Evaluation of Radiation Dose and Damage to the Normal Skin / Hiroshi Fukuda, Junichi Hiratsuka, Chihiro Honda, Tooru Kobayashi, Kazuo Yoshino, Hiroshi Karashima, Jutaro Takahashi, Yoshinao Abe, Keiji Kanda, Masamitsu Ichihashi and Yutaka Mishima  /p.215
30. RBE of BNCT for Human Skin-Re-Evaluation Based on Ten Cases of Human Melanoma BNCT/ Junichi Hiratsuka, Hiroshi Fukuda, Tooru Kobayashi, Hiroshi Karashima, Kazuo Yoshino, Chihiro Honda, Nobutoshi Wadabayashi and Yutaka Mishima  /p.223
31. 結節型メラノーマの熱中性子線量分布一動物を用いた前臨床試験とヒト臨床データの解析一/ 平塚純一、辛嶋博、福田寛、本田千博、和田林展年、 古林徹、神田啓治、三嶋豊
    Thermal Neutron Distribution in Nodular Melanoma for BNCT-Data Analysis of Pre-Clinical Study and Clinical Trial―
    Junichi Hiratsuka, Hiroshi Karashima, Hiroshi Fukuda, Chihiro Honda, Nobutoshi Wadabayashi, Tooru Kobayashi, Keiji Kanda and Yutaka Mishima  /p.227
32. A Basic Concept for PET-BNCT System / Yoshio Imahori, Satoshi Ueda, Yoshio Ohmori, Eiji Yoshino, Koji Ono, Tooru Kobayashi, Tatsuo Ido and Yutaka Mishima  /p.233
33. Positron Emission Tomography and Boron Neutron Capture Therapy System to the Patient with Malignant Brain Tumor
    -The First Clinical Trial Using ¹⁰B-BPA/ Satoshi Ueda, Yoshio Imahori, Yoshio Ohmori, Eiji Yoshino, Koji Ono, Tooru Kobayashi, Masao Takagaki, Yoshifumi Oda, Tatsuo Ido and Yutaka Mishima  /p.240
34. Assessment of Photon Contributions in Gadolinium Neutron/ Capture Reactions-A Preliminary Study—/ Koichi Tokuuye, Nobuhiko Tokita, Yasuyuki Akine, Tooru Kobayashi, and Keiji Kanda  /p.246