{"id":4567,"date":"2026-05-30T12:43:33","date_gmt":"2026-05-30T03:43:33","guid":{"rendered":"https:\/\/adm.rri.kyoto-u.ac.jp\/pub\/?p=4567"},"modified":"2026-05-30T12:43:33","modified_gmt":"2026-05-30T03:43:33","slug":"kurri-tr-356","status":"publish","type":"post","link":"https:\/\/adm.rri.kyoto-u.ac.jp\/pub\/kurri-tr-356\/","title":{"rendered":"KURRI-TR-356"},"content":{"rendered":"\n
\"\"<\/figure>\n\n\n\n

\u30db\u30a6\u7d20\u71b1\u4e2d\u6027\u5b50\u6355\u6349\u7642\u6cd5\u306e\u9069\u5fdc\u62e1\u5927\u306b\u95a2\u3059\u308b\u7814\u7a76
\u526f\u984c\uff1a\u5358\u30af\u30ed\u30fc\u30f3\u6297\u4f53\u5229\u7528\u306e10<\/sup>B\u96c6\u7a4d\uff0c\u5373\u767a\u03b3\u7dda\u306b\u3088\u308b\u764c\u8a3a\u65ad\uff0cL\u4f53\u5358\u96e2\u306b\u3088\u308b10B-BPA\u306e\u85ac\u52b9\u5897\u5f37
Investigation for the Extended Application of Melanoma Boron Neutron Capture Therapy<\/p>\n\n\n\n

\u958b\u50ac\u65e5\uff1a1991\u5e7411\u6708\u3000(November, 1991)
\u7de8\u96c6\uff1a\u4e09\u5cf6\u8c4a
Edited by\uff1a Yutaka Mishima<\/p>\n\n\n\n

\u76ee\u6b21<\/strong><\/p>\n\n\n\n

Preface \/ Editor : Yutaka Mishima\uff08Professor & Chairman, Department of Dermatology, Director, Special Institute of Cancer Neutron Capture Therapy, Kobe University School of Medicine\uff09\u2175<\/p>\n\n\n\n

\u5e8f\u6587 \/ \u4e09\u5cf6\u8c4a\uff08\u795e\u6238\u5927\u5b66\u533b\u5b66\u90e8\u76ae\u819a\u79d1\u5b66\u8b1b\u5ea7 \u6559\u6388 \u719f\u4e2d\u6027\u5b50\u6355\u6349\u764c\u7642\u6cd5\u7279\u5225\u7814\u7a76\u65bd\u8a2d\u9577\uff09\u2176<\/p>\n\n\n\n

I. \u672c\u7814\u7a76\u306e\u76ee\u7684\u3068\u73fe\u6cc1-viii<\/p>\n\n\n\n

II. \u7814\u7a76\u767a\u8868<\/p>\n\n\n\n

1. Treatment of Malignant Melanoma by Single Thermal Neutron\/ Capture Therapy with Melanoma-Seeking 10<\/sup>B-compound\uff08Yutaka Mishima, Chihiro Honda, Masamitsu Ichihashi, Hidefumi Obara, Junichi Hiratsuka, Hiroshi Fukuda, Hiroshi Karashima, Tooru Kobayashi, Keiji Kanda and Kazuo Yoshino\uff09  \/p.1<\/p>\n\n\n\n

2. Treatment of Malignant Melanoma by Selective Thermal Neutron Capture Therapy Using Melanoma-Seeking Compound\/ \uff08Yutaka Mishima, Masamitsu Ichihashi, Masayuki Tsuji, Susumu Hatta, Masato Ueda, Chihiro Honda and Tatsuo Suzuki\uff09  \/p.3<\/p>\n\n\n\n

3. \u30e1\u30e9\u30ce\u30fc\u30de\u65b0\u653e\u5c04\u7e01\u7642\u6cd5\uff0d\u30d2\u30c8\u8b33\u6027\u9ed2\u8272\u5398\u306e\u71b1\u4e2d\u6027\u5b50\u6355\u6349\u7642\u6cd5\u3092\u4e2d\u5fc3\u306b\uff0d \/ \u4e09\u5cf6\u8c4a\uff0c\u672c\u7530\u5343\u535a\uff0c\u5e02\u6a4b\u6b63\u5149<\/p>\n\n\n\n

Melanoma New-Radiotherapy :Thermal Neutron Capture Therapy of Malignant Melanoma \/ Yutaka Mishima, Chihiro Honda and Masamitsu Ichihashi  \/p.8<\/p>\n\n\n\n

4. Further In Vitro Radiobiological Analysis on 10<\/sup>B-BPA BNCT of Malignant Melanoma : Correlation of Determined 10B-Content and Cell Killing Effect\/ Masamitsu Ichihashi, Masahiro Shiono, Keizo Yamamura, Atsuko Komura, Yutaka Mishima, Kazuo Yoshino, Tooru Kobayashi, Keiji Kanda, Hiroshi Fukuda and Yoshiki Hori  \/p.21<\/p>\n\n\n\n

5. 4-Borono-2-[18<\/sup>F]Fluoro-D, L-Phenylalanine as a Target Compound\/ for Boron Neutron Capture Therapy : Tumor Imaging Potential with Positron Emission Tomography \/ Kiichi Ishiwata, Tatsuo Ido, Mieko Kawamura, Kazuo Kubota, Masamitsu Ichihashi and Yutaka Mishima  \/p.25<\/p>\n\n\n\n

6. 4-Borono-2-[18<\/sup>F]Fluoro-D, L-Phenylalanine : A Possible Tracer for Melanoma Diagnosis with PET\/ Kiichi Ishiwata, Tatsuo Ido, Chihiro Honda, Mieko Kawamura, Masamitsu Ichihashi and Yutaka Mishima  \/p.31<\/p>\n\n\n\n

7. Synthesis and Radiation Dosimetry of 4-Borono-2-[18<\/sup>F]Fluoro-D,L-Phenylalanine : A Target Compound for PET and Boron Neutron Capture Therapy\/ Kiichi Ishiwata, Tatsuo Ido, Alvaro A. Mejia, Masamitsu Ichihashi and Yutaka Mishima  \/p.48<\/p>\n\n\n\n

8. Antigen Dynamics in Melanocytic and Nevocytic Melanoma \/ Oncogenesis : Anti-Ganglioside and Anti-ras<\/em> p21 Antibodies as Markers of Tumor Progression\/ Keizo Yamamura and Yutaka Mishima  \/p.52<\/p>\n\n\n\n

9. Different Fine Binding Specificities of Monoclonal Antibodies to Disialoganglioside GD2 \/ Tadashi Tai, Ikuo Kawashima, Nobuhiko Tada and Kazuo Dairiki  \/p.61<\/p>\n\n\n\n

10. Mouse Monoclonal Antibodies Detecting Disialogangliosides on Mouse and Human T Lymphomas \/ Ikuo Kawashima, Nobuhiko Tada, Shuji Ikegami, Shuji Nakamura, Ryuzo Ueda and Tadashi Tai  \/p.67<\/p>\n\n\n\n

11. \u6297\u30ac\u30f3\u30b0\u30ea\u30aa\u30b7\u30c9(GD2)\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\u6295\u4e0e\u306b\u3088\u308bT\u7d30\u80de\u767d\u8840\u75c5\u306b\u5bfe\u3059\u308b\u6297\u816b\u760d\u52b9\u679c \/ \u591a\u7530\u4f38\u5f66\u3001\u7530\u4e95\u76f4\u3001\u4e0a\u7530\u9f8d\u4e09\u3001\u9ed2\u6d25\u9686\u5b8f\u3001\u85e4\u68ee\u9686\u592b<\/p>\n\n\n\n

Experimental Serotherapy of Mouse T-cell Leukemia with Anti-Ganglioside (GD2)Monoclonal Antibodies \/ Nobuhiko Tada, Tadasi Tai, Ryuzo Ueda, Takahiro Kurotsu and Takao Fujimori  \/p.75<\/p>\n\n\n\n

12. Characterization of Mouse Melanoma Associated Antigen and Genomic Cloning\/ Masaru Taniguchi, Kazuaki Takahashi, Yoshio Hirabayashi, Masatoshi Tagawa, Tohru Sakamoto, Akira Okitsu and Nobumi Kusakabe  \/p.82<\/p>\n\n\n\n

13. Isolation of Genomic DNA Controlling Mouse Melanoma Antigen Defined by Monoclonal Antibody \/ Akira Okitsu, Masatoshi Tagawa, Yoshio Tamura, Masamoto Kanno, Hisahiro Matsubara, Toshihiro Ito, Kenji Imai, Kazuhiro Shigemoto, Ikuro Nakamura, Haruhiko Koseki, Yun-Fai Lau and Masaru Taniguchi  \/p.90<\/p>\n\n\n\n

14. Characterization of a Melanoma Antigen with a Mouse-specific Epitope Recognized by a Monoclonal Antibody with Antimetastatic Ability \/ Hisako Sakiyama, Eiki Matsushita, Ichiro Kuwahara, Mutsumi Nozue, Toshiko Takahashi and Masaru Taniguchi  \/p.98<\/p>\n\n\n\n

15. Melanoma Antigen and Transforming Gene\/ Masatoshi Tagawa, Tohru Sakamoto, Akira Okitsu, Yoshio Tamura, Kenji Imai, Hisahiro Matsubara and Masaru Taniguchi  \/p.104<\/p>\n\n\n\n

16. Genomic DNA with Transformation-Related Activity and Melanoma Antigen Expression \/ Masatoshi Tagawa, Tohru Sakamoto, Yoshio Tamura, Kenji Imai, Toshihiro Ito, Hisahiro Matsubara, Masamoto Kanno, Kazuhiro Shigemoto, Haruhiko Koseki and Masaru Taniguchi  \/p.113<\/p>\n\n\n\n

17. Density of GM3 with Normal Primary Structure Determines Mouse Melanoma Antigenicity : a New Concept of Tumor Antigen \/ Yoshitada Harada, Minoru Sakatsume, Gustavo A. Nores, Sen-itiroh Hakomori and Masaru Taniguchi  \/p.118<\/p>\n\n\n\n

18. Properties of Mouse Melanoma Antigen and Its Secretion Mechanism from the Cell Surface\/ Ichiro Kuwabara, Masatoshi Tagawa, Yoshitada Harada, Toshihiro Ito and Masaru Taniguchi  \/p.123<\/p>\n\n\n\n

19. Induction of Mouse Anti-melanoma Cytotoxic and Suppressor T Cells in vitro by an Artificial Antigen, GM3-lactone \/ Yoshitada Harada, Minoru Sakatsume and Masaru Taniguchi  \/p.130<\/p>\n\n\n\n

20. Cross-Species Melanoma Antigen\/ Masaru Taniguchi, Ichiro Kuwabara, Yoshitada Harada, Minoru Sakazurne and Kumeo Ono  \/p.135<\/p>\n\n\n\n

21. Mouse Melanoma Antigens and Autoreactive T Cell Responses \/ Akihiro Kurosu, Minoru Sakatsume, Ichiro Kuwabara, Masato Kantake, Harhiko Koseki and Masaru Taniguchi  \/p.144<\/p>\n\n\n\n

22. \u30e2\u30ce\u3001\u30b8\u53ca\u3073\u30c8\u30ea\uff08\u30e2\u30ce\u30ab\u30eb\u30dd\u30ad\u30b7\u30a2\u30eb\u30ad\u30eb\uff09\u30a2\u30f3\u30e2\u30cb\u30aa\u30fc\u30a6\u30f3\u30c7\u30ab \u30d2\u30c9\u30ed\u30c9\u30c7\u30ab\u30dd\u30ec\u30fc\u30c8(-1) \/\u4e2d\u5ddd\u4fca\u592b\uff0e\u4e09\u5cf6\u8c4a<\/p>\n\n\n\n

Mono-, Di-, and Tri-(Monocarboxyalkyl)ammonio-undecahydrododecaborates(-1) \/ Toshia Nakagawa and Yutaka Mishima  \/p.155<\/p>\n\n\n\n

23. Thermal Neutron Capture Therapy of Malignant Melanoma Using 10<\/sup>B-Monoclonal Antibodies : In Vitro and In vivo Analysis \/ Atsuko Komura, Toshio Nakagawa Masamitsu Ichihashi and Yutaka Mishima\u00a0 \/p.175<\/p>\n\n\n\n

24. Comparative Analytical Studies on Selective Boron Accumulation in Hamster Melanoma by Different Administration Routes of 10<\/sup>B1<\/sub>-BPA for Neutron Capture Therapy \/ Chihiro Honda, Masahiro Shiono, Nobutoshi Wadabayashi, Susumu Hatta, Masamitsu Ichihashi, Yutaka Mishima, Tooru Kobayashi, Keiji Kanda, Kazuo Yoshino and Yoshiki Hori  \/p.192<\/p>\n\n\n\n

25. In Situ Detection of Cutaneous Melanoma by Prompt Gamma-Ray Spectrometry Using Melanoma-Seeking 10<\/sup>B-Dopa Analogue\/ Chihiro Honda, Yutaka Mishima, Masamitsu Ichihashi and Susumu Hatta  \/p.200<\/p>\n\n\n\n

26. Improvement of Calculational Technique on Flux Distributions in a Water Phantom Caused by Narrow Thermal Neutron Beam for Neutron Capture Therapy \/ Masayuki Ono, Tooru Kobayashi and Keiji Kanda  \/p.209<\/p>\n\n\n\n

27. Reevaluation of Thermal Neutron Field of the KUR Heavy Water Facility for Biomedical Uses : Optimization of Bismuth, Heavy Water and Graphite Layers\/ Shusuke Fujihara, Tooru Kobayashi and Keiji Kanda  \/p.216<\/p>\n\n\n\n

28. Boron-10 Quantitative Analysis of Neutron Capture Therapy on Malignant Melanoma by Spectrophotometric a-Track Reading \/ Masao Takagaki and Yutaka Mishima  \/p.227<\/p>\n\n\n\n

29. Optical Resolution of 10B-p-Boronophenylalanine for Neutron Capture Therapy\/ Kazuo Yoshino, Takanobu Maruyama, Satomi Mieda, Motoko Ogawa, Ikuko Umeda, Yoshihiro Mori, Yutaka Mishima and Masamitsu Ichihashi  \/p.232<\/p>\n\n\n\n

30. Increased Boron Uptake by Hamster Melanoma Using L-Isomer B1<\/sub>-BPA for Neutron Capture Therapy \/ Chihiro Honda, Masahiro Shiono, Nobutoshi Wadabayashi, Masamitsu Ichihashi, Yutaka Mishima, Kazuo Yoshino, Tooru Kobayashi, Keiji Kanda, Yoshiki Hori and Hiroshi Karashirna  \/p.243<\/p>\n\n\n\n

31. In Vivo Cellular Pharmacology on the Selective Affinity of 10<\/sup>B1<\/sub>-BPA for Malignant Melanoma \/Masahiro Shiono, Takakazu Shibata, Chihiro Honda, Nobutoshi Wadabayashi, Masamitsu Ichihashi, Yoshiki Hori, Kazuo Yoshino and Yutaka Mishima  \/p.249<\/p>\n\n\n\n

32. Rapid Spectrophotometric Determination of Trace Boron in Tissues\/ for Boron Neutron Capture Therapy \/ Kazuo Yoshino, Chie Nishio, Eri Ubukata, Takanobu Maruyama, Yoshihiro Mori, Yutaka Mishima, Chihiro Honda, Masahiro Shiono, Nobutoshi Wadabayashi, Tooru Kobayashi and Keiji Kanda  \/p.253<\/p>\n\n\n\n

33. \u60aa\u6027\u9ed2\u8272\u816b\u752810<\/sup>B \u5316\u5408\u7269\u30c9\u30fc\u30d1\u30dd\u30ec\u30fc\u30c8\u3068p-\u30dd\u30ed\u30ce\u30d5\u30a7\u30cb\u30fc\u30eb\/ \u30a2\u30e9\u30cb\u30f3\u306e\u5316\u5b66\u7684\u6319\u52d5\u3068\u4e2d\u6027\u5b50\u6355\u6349\u7642\u6cd5 \/\u5409\u91ce\u548c\u592b\u3001\u68ee\u82b3\u5f18\u3001\u57a3\u82b1\u79c0\u6b66<\/p>\n\n\n\n

Chemical Behaviors of 10B dopa Borate and 10B-p-Boronophenylalanine for Boron Neutron Capture Therapy \/ Kazuo Yoshino, Yoshihiro Mori and Hidetake Kakihana  \/p.259<\/p>\n\n\n\n

34. 10<\/sup>B\u5316\u5408\u7269(BPA \u95a2\u9023\uff09\u306e\u69cb\u9020\u3068\u305d\u306e\u71b1\u4e2d\u6027\u5b50\u6355\u6349\u7642\u6cd5\u3068\u306e\u95a2\u9023\/ \u5800\u8d8a\u79c0\u5f66\u3001\u5411\u7530\u653f\u7537\u3001\u57a3\u82b1\u79c0\u6b66\u3001\u5409\u91ce\u548c\u592b\u3001\u68ee\u82b3\u5f18<\/p>\n\n\n\n

Relationship between Structures of BPA-related 10<\/sup>B-compoundsand Their Uses in Thermal Neutron Capture Therapy \/ Hidehiko Horikoshi, Masao Mukaida, Hidetake Kakihana, Kazuo Yoshino and Yoshihiro Mori   \/p.269<\/p>\n\n\n\n

35. Acute Toxicity of n<\/sup>B-Paraboronophenylalanine-Oral Administration \/ Kohtaro Taniyama, Akira Itoh and Chikako Tanaka  \/p.277<\/p>\n\n\n\n

36. RBE of a Thermal Neutron Beam and the 10<\/sup>B(n, \u03b1) 7<\/sup>Li Reaction on Cultured B-16 Melanoma Cells \/ Hiroshi Fukuda,. Tooru Kobayashi, Taiju Matsuzawa, Keiji Kanda, Masamitsu Ichihashi and Yutaka Mishima  \/p.280<\/p>\n\n\n\n

37. \u57fa\u790e\u9762\u304b\u3089\u307f\u305f\u816b\u760d\u6cbb\u7652\u4e00\u816b\u760d\u5e79\u7de8\u817f\u6570\u306e\u91cd\u8981\u6027\u306b\u3064\u3044\u3066\u4e00\/ \u5b89\u85a6\u8208\u4e00\u3001\u798f\u7530\u5bdb\u3001\u8352\u5c45\u7adc\u96c4\u3001\u4e2d\u91ce\u9686\u53f2<\/p>\n\n\n\n

Tumor Control-Significance of the Stem Cell Number \/ Koichi Ando, Hiroshi Fukuda, Tatsuo Arai and Takashi Nakano  \/p.289<\/p>\n\n\n\n

38. Mathematical Analysis of the Survival of HeLa S3 Cells Following \/ Neutron Capture Radiation : Calculation of RBE by a Linear- Quadratic Model \/ Yowri Ujeno, Mitsuhiko Akaboshi, Hirotoshi Maki and Kenichi Kawai  \/p.293<\/p>\n\n\n\n

39. The Radiation Biology of Boron Neutron Capture Therapy \/ Hiroshi Utsumi  \/p.299<\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

\u30db\u30a6\u7d20\u71b1\u4e2d\u6027\u5b50\u6355\u6349\u7642\u6cd5\u306e\u9069\u5fdc\u62e1\u5927\u306b\u95a2\u3059\u308b\u7814\u7a76\u526f\u984c\uff1a\u5358\u30af\u30ed\u30fc\u30f3\u6297\u4f53\u5229\u7528\u306e10B\u96c6\u7a4d\uff0c\u5373\u767a\u03b3\u7dda\u306b\u3088\u308b\u764c\u8a3a\u65ad\uff0cL\u4f53\u5358\u96e2\u306b\u3088\u308b10B-BPA\u306e\u85ac\u52b9\u5897\u5f37Investigation for the Extended Applicat […]<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"12","format":"standard","meta":{"_uag_custom_page_level_css":"","_locale":"ja","_original_post":"https:\/\/adm.rri.kyoto-u.ac.jp\/pub\/?p=4567","footnotes":""},"categories":[17],"tags":[],"class_list":["post-4567","post","type-post","status-publish","format-standard","hentry","category-technical-repprt","ja"],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"nakatani","author_link":"https:\/\/adm.rri.kyoto-u.ac.jp\/pub\/author\/nakatani\/"},"uagb_comment_info":0,"uagb_excerpt":"\u30db\u30a6\u7d20\u71b1\u4e2d\u6027\u5b50\u6355\u6349\u7642\u6cd5\u306e\u9069\u5fdc\u62e1\u5927\u306b\u95a2\u3059\u308b\u7814\u7a76\u526f\u984c\uff1a\u5358\u30af\u30ed\u30fc\u30f3\u6297\u4f53\u5229\u7528\u306e10B\u96c6\u7a4d\uff0c\u5373\u767a\u03b3\u7dda\u306b\u3088\u308b\u764c\u8a3a\u65ad\uff0cL\u4f53\u5358…","_links":{"self":[{"href":"https:\/\/adm.rri.kyoto-u.ac.jp\/pub\/wp-json\/wp\/v2\/posts\/4567","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/adm.rri.kyoto-u.ac.jp\/pub\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/adm.rri.kyoto-u.ac.jp\/pub\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/adm.rri.kyoto-u.ac.jp\/pub\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/adm.rri.kyoto-u.ac.jp\/pub\/wp-json\/wp\/v2\/comments?post=4567"}],"version-history":[{"count":2,"href":"https:\/\/adm.rri.kyoto-u.ac.jp\/pub\/wp-json\/wp\/v2\/posts\/4567\/revisions"}],"predecessor-version":[{"id":5024,"href":"https:\/\/adm.rri.kyoto-u.ac.jp\/pub\/wp-json\/wp\/v2\/posts\/4567\/revisions\/5024"}],"wp:attachment":[{"href":"https:\/\/adm.rri.kyoto-u.ac.jp\/pub\/wp-json\/wp\/v2\/media?parent=4567"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/adm.rri.kyoto-u.ac.jp\/pub\/wp-json\/wp\/v2\/categories?post=4567"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/adm.rri.kyoto-u.ac.jp\/pub\/wp-json\/wp\/v2\/tags?post=4567"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}