{"id":4568,"date":"2026-05-30T12:49:47","date_gmt":"2026-05-30T03:49:47","guid":{"rendered":"https:\/\/adm.rri.kyoto-u.ac.jp\/pub\/?p=4568"},"modified":"2026-05-30T12:49:47","modified_gmt":"2026-05-30T03:49:47","slug":"kurri-tr-357","status":"publish","type":"post","link":"https:\/\/adm.rri.kyoto-u.ac.jp\/pub\/kurri-tr-357\/","title":{"rendered":"KURRI-TR-357"},"content":{"rendered":"\n
\"\"<\/figure>\n\n\n\n

\u30d2\u30c8\u9ed2\u8272\u816b\u306e\u30e1\u30e9\u30cb\u30f3\u4ee3\u8b1d\u6d3b\u6027\u89aa\u548c\u6027B-10 \u5316\u5408\u7269\u306b\u3088\u308b\u9078\u629e\u7684\u71b1\u4e2d\u6027\u5b50\u6355\u6349\u7642\u6cd5
Selective Thermal Neutron Capture Therapy of Malignant Melanoma Using Melanogenesis-seeking 10<\/sup>B-compounds<\/p>\n\n\n\n

1991\u5e7411\u6708\u3000(November, 1991)\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0
\u7de8\u96c6\uff1a\u4e09\u5cf6\u8c4a
Edited by\uff1a Yutaka Mishima<\/p>\n\n\n\n

\u76ee\u6b21<\/strong><\/p>\n\n\n\n

Preface Editor : Yutaka Mishima Professor & Chairman, Department of Dermatology, Director, Special Institute of Cancer Neutron Capture Therapy, Kobe University School of Medicine\/ v<\/p>\n\n\n\n

\u5e8f\u6587\u30a8\u30c7\u30a4\u30bf\u30fc\uff1a\u4e09\u5cf6\u8c4a\uff08\u795e\u6238\u5927\u5b66\u533b\u5b66\u90e8\u76ae\u819a\u79d1\u5b66\u8b1b\u5ea7\u6559\u6388 \u71b1\u4e2d\u6027\u5b50\u6355\u6349\u764c\u7642\u6cd5\u7279\u5225\u7814\u7a76\u65bd\u8a2d\u9577\uff09\u2176<\/p>\n\n\n\n

\u2160. \u672c\u7814\u7a76\u306e\u76ee\u7684\u3068\u73fe\u6cc1 \u2176<\/p>\n\n\n\n

\u2161. \u7814\u7a76\u767a\u8868<\/p>\n\n\n\n

1. Advances in the Control of Human Cutaneous Primary and Metastatic Melanoma by Thermal Neutron Capture Therapy \/Yutaka Mishima, Masamitsu Ichihashi, Chihiro Honda, Masahiro Shiono, Toshio Nakagawa, Hidefumi Ohara, Junji Shirakawa, Junichi Hiratsuka, Keiji Kanda, Tooru Kobayashi, Tetsuya Nozaki, Otohiko Aizawa, Tadashi Sato, Hiroshi Karashima, Kazuo Yoshino and Hiroshi Fukuda  \/p.1<\/p>\n\n\n\n

2. 10<\/sup>B1<\/sub>-BPA Administration to Human Melanoma Patients Boron Analytical Studies for Neutron Capture Therapy \/ Chihiro Honda, Masahiro Shiono, Nobutoshi Wadabayashi, Susumu Hatta, Masamitsu Ichihashi, Yutaka Mishima, Kazuo Yoshino, Tooru Kobayashi, Keiji Kanda and Yoshiki Hori  \/p.7<\/p>\n\n\n\n

3. First Human Clinical Trial of Melanoma Neutron Capture : Diagnosis and Therapy \/ Yutaka Mishima, Masamitsu Ichihashi, Susumu Hatta, Chihiro Honda, Keizo Yamamura, Toshio Nakagawa, Hidefumi Obara, Junji Shirakawa, Junichi Hiratsuka, Kohtaro Taniyama, Chikako Tanaka, Keiji Kanda, Tooru Kobayashi, Takashi Sato, Masahiro R. Ishida, Yowri Ujeno, Masaji Takahashi, Mitsuyuki Abe, Tetsuya Nozaki, Otohiko Aizawa, Tetsuo Matsumoto, Tadashi Sato, Hiroshi Karashima, Kazuo Yoshino and Hiroshi Fukuda  \/p.19<\/p>\n\n\n\n

4. Selective Thermal Neutron Capture Therapy and Diagnosis of Malignant Melanoma : From Basic Studies to First Clinical Treatment \/ Yutaka Mishima, Masamitsu Ichihashi, Susumu Hatta, Chihiro Honda, Akihiro Sasase, Keizo Yamamura, Keiji Kanda, Tooru Kobayashi and Hiroshi Fukuda   \/p.23<\/p>\n\n\n\n

5. \u60aa\u6027\u30e1\u30e9\u30ce\u30fc\u30de\/ \u4e09\u5cf6\u8c4a\u3001\u672c\u7530\u5343\u535a<\/p>\n\n\n\n

Malignant Melanoma\/ Yutaka Mishima and Chihiro Honda  \/p.33<\/p>\n\n\n\n

6. \u30d2\u30c8\u60aa\u6027\u9ed2\u8272\u816b\u306e\u71b1\u4e2d\u6027\u5b50\u6355\u6349\u7642\u6cd5\u306b\u3088\u308b\u6cbb\u7652\/ \u4e09\u5cf6\u8c4a\u3001\u672c\u7530\u5343\u535a\u3001\u5e02\u6a4b\u6b63\u5149\u3001\u5869\u91ce\u6b63\u535a<\/p>\n\n\n\n

Cure of Human Malignant Melanoma by Thermal Neutron Capture Therapy \/Yutaka Mishima, Chihiro Honda, Masamitsu Ichihashi and Masahiro Shiono  \/p.40<\/p>\n\n\n\n

7. \u60aa\u6027\u9ed2\u8272\u816b\u306e\u71b1\u4e2d\u6027\u5b50\u6355\u6349\u7642\u6cd5\/ \u5e02\u6a4b\u6b63\u5149\u3001\u4e09\u5cf6\u8c4a<\/p>\n\n\n\n

Thermal Neutron Capture Therapy for Malignant Melanoma\/ Masamitsu Ichihashi and Yutaka Mishima  \/p.46<\/p>\n\n\n\n

8. In Vitro Evaluation of 10<\/sup>B-BPA for Melanoma at MOAT A-Joint Work between Japan and Australia BNCT Research Teams \/ Masamitsu Ichihashi, Hiroshi Fukuda, J. Keith Brown, Max H. Mountford, Barry J. Allen, J. Gerald Wilson and Yutaka Mishima  \/p.53<\/p>\n\n\n\n

9. Improved Bioavailability of Para-Boronophenylalanine by Cyclodextrin Complexation \/ Hisakatsu Hatanaka, Fusao Komada, Masahiro Shiono, Yutaka Mishima and Katsuhiko Okumura  \/p.57<\/p>\n\n\n\n

10. Relation between Tolerance Dose of Skin and Boron-10 Concentration in Neutron Capture Therapy for Cutaneous Melanoma \/ Tooru Kobayashi, Keiji Kanda, Yowri Ujeno, Hiroshi Fukuda, Koichi Ando, Yutaka Mishima, Masamitsu Ichihashi and Junichi Hiratsuka  \/p.68<\/p>\n\n\n\n

11. The Relative Biological Effectiveness of 10<\/sup>B-Neutron Capture Therapy for Early Skin Reaction in the Hamster \/ Junichi Hiratsuka, Hiroshi Fukuda, Tooru Kobayashi, Hiroshi Karashima, Kazuo Yoshino, Yoshinari Imajo and Yutaka Mishima  \/p.72<\/p>\n\n\n\n

12. In Situ Measurement on 10<\/sup>B Concentrations and Absorbed Dose\/ Estimations in Human Malignant Melanoma Treated by BNCT \/ Tooru Kobayashi, Keiji Kanda and Yutaka Mishima  \/p.78<\/p>\n\n\n\n

13. Measurement and Analysis on Neutron Flux Distributions in a Heavy Water Phantom Using the KUR Neutron Guide Tube for BNCT \/ Tooru Kobayashi, Masayuki Ono and Keiji Kanda  \/p.81<\/p>\n\n\n\n

14. Effective Thermal Neutron Collimation for Neutron Capture Therapy Using Neutron Absorption and Scattering Reactions \/ Tooru Kobayashi, Shusuke Fujihara and Keiji Kanda  \/p.84<\/p>\n\n\n\n

15. \u4eac\u5927\u7089\u306b\u304a\u3051\u308b\u539f\u5b50\u7089\u533b\u7642\u306b\u95a2\u3059\u308b\u6cbb\u7642\u7167\u5c04\u30b7\u30b9\u30c6\u30e0\/ \u53e4\u6797\u5fb9\u3001\u795e\u7530\u5553\u6cbb\u3001\u4e0a\u91ce\u967d\u91cc\u3001\u77f3\u7530\u653f\u5f18<\/p>\n\n\n\n

Irradiation System for Boron Neutron Capture Therapy in the KUR \/ Tooru Kobayashi, Keiji Kanda, Yowri Ujeno and Masahiro R. Ishida  \/p.88<\/p>\n\n\n\n

16. \u4e2d\u6027\u5b50\u6355\u6349\u7642\u6cd5\u306b\u304a\u3051\u308b\u52b9\u679c\u7684\u306a\u71b1\u4e2d\u6027\u5b50\u30b3\u30ea\u30e1\u30fc\u30b7\u30e7\u30f3\u30fc\u71b1\u4e2d\u6027\u5b50\u306e\u6563\u4e71\u4f53\u3068\u5438\u53ce\u4f53\u306e\u6709\u52b9\u5229\u7528\u4e00\/ \u53e4\u6797\u5fb9\uff0c\u795e\u7530\u5553\u6cbb\uff0c\u85e4\u539f\u79c0\u4ecb<\/p>\n\n\n\n

Effective Thermal Neutron Collimation for Neutron Capture Therapy : Usage of Neutron Scattering and Absorbing Materials\/ Tooru Kobayashi, Keiji Kanda and Shusuke Fujihara\u00a0 \/p.94<\/p>\n\n\n\n

17. Biomedical Irradiation System for Boron Neutron Capture. Therapy at the Kyoto University Reactor \/ Tooru Kobayashi, Keiji Kanda, Yowri Ujeno and Masahiro R. Ishida  \/p.102<\/p>\n\n\n\n

18. \u307b\u3046\u7d20\u4e2d\u6027\u5b50\u6355\u6349\u7642\u6cd5\u306b\u304a\u3051\u308b\u5438\u53ce\u7dda\u91cf\u8a55\u4fa1\u3088\u308a\u307f\u305f\u6cbb\u7642\u7167\u5c04\u6761\u4ef6\/ \uff0d\u8868\u5728\u3059\u308b\u8b33\u6027\u9ed2\u8272\u9e97\u306b\u5bfe\u3059\u308b\u691c\u8a0e\u4e00\/ \u53e4\u6797\u5fb9\u3001\u795e\u7530\u5553\u6cbb\u3001\u4e0a\u91ce\u967d\u91cc\u3001\u798f\u7530\u5bdb\u3001\u5b89\u85e4\u8208\u30fc\u3001\u5e73\u585a\u7d14\u4e00\u3001\u4e09\u5cf6\u8c4a\u3001\u5e02\u6a4b\u6b63\u5149<\/p>\n\n\n\n

Irradiation Conditions Based on Absorbed Dose Estimation in Boron Neutron Capture Therapy for Superficially Located Malignant Melanoma \/ Tooru Kobayashi, Keiji Kanda, Yowri Ujerio, Hiroshi Fukuda, Koichi Ando, Junichi Hiratsuka, Yutaka Mishima and Masamitsu Ichihashi  \/p.121<\/p>\n\n\n\n

19. \u4eac\u5927\u539f\u5b50\u7089\u306b\u304a\u3051\u308b\u533b\u7642\u7167\u5c04\u7d4c\u9a13\uff0d\u7dda\u91cf\u306e\u6e2c\u5b9a\u304a\u3088\u3073\u305d\u306e\u8a55\u4fa1\u304b\u3089\u307f\u305f\u7167\u5c04\u6280\u8853\u7684\u5074\u9762\uff0d \/\u53e4\u6797\u5fb9\u3001\u795e\u7530\u5553\u6cbb\u3001\u4f50\u85e4\u5b5d\u53f8\u3001\u5c0f\u91ce\u5149\u4e00\u3001\u79cb\u5409\u6052\u548c\u3001\u6d77\u8001\u6ca2\u5fb9\u3001\u7530\u5d0e\u8aa0\u53f8\u3001\u4e0a\u91ce\u967d\u91cc\u3001\u82a5\u7530\u656c\u4e09\u3001\u7560\u4e2d\u5766\u3001\u4e09\u5cf6\u8c4a\u3001\u7e54\u7530\u7965\u53f2<\/p>\n\n\n\n

Clinical Experiences for Neutron Capture Therapy Using the KUR : Technical Aspects Related to Thermal Neutron Irradiation and Its Dose Estimation \/Tooru Kobayashi, Keiji Kanda, Takashi Sato, Koichi Ono, Tunekazu Akiyoshi, Toru Ebisawa, Seiji Tasaki, Yowri Ujeno, Keizo Akuta, Hiroshi Hatanaka, Yutaka Mishima and Yoshifumi Oda  \/p.133<\/p>\n\n\n\n

20. p-Boronophenylalanine-Saccharide Complexes for Boron Neutron Capture Therapy\/ Kazuo Yoshino, Yasuhiko Kinoshita, Yoshihiro Mori, Hidetake Kakihana and Yutaka Mishima  \/p.141<\/p>\n\n\n\n

21. Improvement of Solubility of p-Boronophenylalanine by Complex Formation with Monosaccharides \/ Kazuo Yoshino, Akio Suzuki, Yosihiro Mori, Hidetake Kakihana, Chihiro Honda, Yutaka Mishima, Tooru Kobayashi and Keiji Kanda  \/p.145<\/p>\n\n\n\n

22. Tolerance Limits of the Normal Skin Treated by a Single Thermal Neutron Capture Therapy \/ Hiroshi Fukuda, Koichi Ando, Chihiro Honda, Masamitsu Ichihashi, Yutaka Mishima, Junichi Hiratsuka, Tooru Kobayashi and Keiji Kanda  \/p.148<\/p>\n\n\n\n

23. \u71b1\u4e2d\u6027\u5b50\u6355\u6349\u6cbb\u7642\u306b\u3088\u308b\u5438\u53ce\u7e01\u91cf\u306e\u8a55\u4fa1\u4e0a\u306e\u554f\u984c\u70b9\/ \u798f\u7530\u5bdb\u3001\u5b89\u85e4\u8208\u4e00\u3001\u53e4\u6797\u5fb9\u3001\u795e\u7530\u5553\u6cbb\u3001\u5e02\u6a4b\u6b63\u5149\u3001\u4e09\u5cf6\u8c4a<\/p>\n\n\n\n

Estimation of Absorbed Dose by Thermal Neutron Capture Therapy : Theoretical Basis and Problems \/ Hiroshi Fukuda, Koichi Ando, Tooru Kobayashi, Keiji Kanda, Masamitsu Ichihashi and Yutaka Mishima  \/p.151<\/p>\n\n\n\n

24. \u71b1\u4e2d\u6027\u5b50\u6355\u6349\u7642\u6cd5\u306b\u304a\u3051\u308b\u7406\u8ad6\u7684\u4e88\u60f3\u53cd\u5fdc\u3068\u81e8\u5e8a\u53cd\u5fdc\u306e\u6bd4\u8f03\u4e00\u6297\u816b\u760d\u52b9\u679c\u3068\u76ae\u819a\u53cd\u5fdc\u306b\u3064\u3044\u3066\u4e00 \/ \u5e73\u585a\u7d14\u4e00\u3001\u53e4\u6797\u5fb9\u3001\u795e\u7530\u5553\u6cbb\u3001\u798f\u7530\u5bdb\u3001\u8f9b\u5d8b\u535a\u3001\u5409\u91ce\u548c\u592b\u3001\u672c\u7530\u5343\u535a\u3001\u5e02\u6a4b\u6b63\u5149\u3001\u4e09\u5cf6\u8c4a<\/p>\n\n\n\n

Comparison of Clinical Response with Calculated Response on Human Melanoma Treated by BNCT :Tumor Effect and Skin Reaction\/ Junichi Hiratsuka, Tooru Kobayashi, Keiji Kanda, Hiroshi Fukuda, Hiroshi Karashima, Kazuo Yoshino, Chihiro Honda, Masamitsu Ichihashi and Yutaka Mishima\u00a0 \/p.154<\/p>\n\n\n\n

25. Two Methods of Anesthetic Management for Neutron Capture Therapy Summary of 8 Cases \/ Junji Shirakawa, Hidefumi Obara, Chihiro Honda and Yutaka Mishima  \/p.163<\/p>\n\n\n\n

26. \u60aa\u6027\u9ed2\u8272\u816b\u306eMRI\u8a3a\u65ad\u306b\u95d8\u3059\u308b\u5b9f\u9a13\u7684\u4e26\u3073\u306b\u81e8\u5e8a\u7684\u7814\u7a76 \uff0d\u30cf\u30e0\u30b9\u30bf\u30fc\u9ed2\u8272\u816b\u306b\u304a\u3051\u308bMR\u50cf\u3068\u75c5\u7406\u50cf\u3068\u306e\u5bfe\u6bd4\u3068\u81e8\u5e8a\u4f8b\u3078\u306e\u5fdc\u7528\uff0d \/\u9752\u6728\u7406\u3001\u6cb3\u91ce\u901a\u96c4\u3001\u4e09\u5cf6\u8c4a<\/p>\n\n\n\n

MR Imaging and Pathologic Correlation on Hamster Malignant Melanoma and Clinical Application\/ Osamu Aoki, Michie Kono and Yutaka Mishima  \/p.167<\/p>\n\n\n\n

27. BNCT Clinical Experiences in KURRI for 1990 and 1991\/ Yowri Ujeno, Keizo Akuta and Yoshifumi Oda  \/p.183<\/p>\n\n\n\n

28. \u901f\u4e2d\u6027\u5b50\u7dda\u306b\u3088\u308b\u60aa\u6027\u9ed2\u8272\u816b\u306e\u6cbb\u7642\u6210\u7e3e\/ \u6052\u5143\u535a\uff0c\u68ee\u7530\u65b0\u516d<\/p>\n\n\n\n

Results of Treatment with Fast Neutron for Malignant Melanoma\/ Hiroshi Tsunemoto and Shinroku Morita  \/p.185<\/p>\n\n\n\n

<\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

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