{"id":4607,"date":"2026-05-30T15:46:31","date_gmt":"2026-05-30T06:46:31","guid":{"rendered":"https:\/\/adm.rri.kyoto-u.ac.jp\/pub\/?p=4607"},"modified":"2026-06-01T08:33:03","modified_gmt":"2026-05-31T23:33:03","slug":"kurri-tr-374","status":"publish","type":"post","link":"https:\/\/adm.rri.kyoto-u.ac.jp\/pub\/kurri-tr-374\/","title":{"rendered":"KURRI-TR-374"},"content":{"rendered":"\n
\"\"<\/figure>\n\n\n\n

\u30d2\u30c8\u60aa\u6027\u9ed2\u8272\u816b\u51685\u5c04\u578b\u306e\u305d\u308c\u305e\u308c\u306b\u5bfe\u5fdc\u3057\u305f \u6700\u9069\u71b1\u4e2d\u6027\u5b50\u6355\u6349\u7642\u6cd5\u306e\u78ba\u7acb
Establishment of Optimal Thermal Neutron Capture Therapy  for 5 Types of Human Malignant Melanoma<\/p>\n\n\n\n

\u958b\u50ac\u65e5\uff1a1993\u5e743\u6708\u3000(March, 1993)
\u7de8\u96c6\uff1a\u4e09\u5cf6\u8c4a
Edited by\uff1a Yutaka Misima<\/p>\n\n\n\n

\u76ee\u6b21<\/strong>\/Contents<\/p>\n\n\n\n

Preface \/ Editor : Yutaka Mishima \/ Honorary Professor\u3001Kobe University School of Medicine Director, Kobe Kaisei Hospital Research Institute Chief\u3001Dermatology Department Director\u3001Mishima Institute for Dermatological Research\uff08vii\uff09<\/p>\n\n\n\n

\u5e8f\u6587 \/ \u30a8\u30c7\u30a3\u30bf\u30fc\uff1a\u4e09\u5cf6\u8c4a\uff08\u795e\u6238\u5927\u5b66\u533b\u5b66\u90e8\u540d\u8a89\u6559\u6388\u3001\u795e\u6238\u6d77\u661f\u75c5\u9662\u7814\u7a76\u6240\u9577\u30fb\u76ae\u819a\u79d1\u90e8\u9577\u3001\u4e09\u5d8b\u76ae\u819a\u79d1\u5b66\u7814\u7a76\u6240\u9577\uff09(\u2178\uff09<\/p>\n\n\n\n

\u2160. \u672c\u7814\u7a76\u306e\u76ee\u7684\u3068\u7814\u7a76\u306e\u73fe\u6cc1\uff0e\uff08\u2179\uff09<\/p>\n\n\n\n

\u2161. \u7814\u7a76\u767a\u8868<\/p>\n\n\n\n

    \n
  1. In Vivo Diagnosis of Human Malignant Melanoma Using Specific Melanoma-Seeking 18<\/sup>F-Compound with Positron Emission Tomography \/ Yutaka Mishima, Yoshio Imahori\u3001ChihiroHonda, Satoshi Ueda and Tatsuo Ido  \/p.1<\/li>\n\n\n\n
  2. Selective Melanoma Thermal Neutron Capture Therapy for Lymph Node Metastases \/ Yutaka Mishima, Chihiro Honda, Masarnitsu Ichihashi, Masahiro Shiono, Nobutoshi Wadabayashi\u3001Hidefurni Obara, Junichi Hiratsuka, Hiroshi Fukuda, Hiroshi Karashima, Keiji Kanda, Tooru Kobayashi and Kazuo Yoshino  \/p.11<\/li>\n\n\n\n
  3. Chairman’s Summary: Malignant Melanoma \/ Yutaka Mishima  \/p.17<\/li>\n\n\n\n
  4. Treatment of Metastatic Melanoma by Neutron Capture Therapy\/ Yutaka Mishima\u3001Masarnitsu Ichihashi, Chihiro Honda\u3001Masahiro Shiono, Toshia Nakagawa, Hidefurni Obara, Junji Shirakawa, Junichi Hiratsuka, Keiji Kanda, Tooru Kobayashi, Tetsuya Nozaki, Otohiko Aizawa, Kazuo Yoshino and Hiroshi Fukuda  \/p.1<\/li>\n\n\n\n
  5. \u591a\u6bb5\u968e\u764c\u5316\u306b\u3088\u308b\u60aa\u6027\u9ed2\u8272\u816b\u306e\u767a\u751f\/\u4e09\u5d8b\u8c4a  \/p.25
    Ontogeny of Human Malignant Melanoma through Multi-Step Carcinogenesis \/Yutaka Mishima<\/li>\n\n\n\n
  6. \u60aa\u6027\u9ed2\u8272\u816b\u306e\u9078\u629e\u7684\u71b1\u4e2d\u6027\u5b50\u6355\u6349\u7642\u6cd5\u00b7 \u30fc\u30d2\u30c8\u75c7\u4f8b\u306e\u6cbb\u7642\u4e00 \/ \u4e09\u5d8b\u8c4a\uff0c\u672c\u7530\u5343\u535a\uff0c\u5869\u91ce\u6b63\u535a\uff0c\u548c\u7530\u6797\u5c55\u5e74\uff0c\u5e02\u6a4b\u6b63\u5149\uff0c\u5c3e\u539f\u79c0\u53f2\uff0c\u798f\u7530\u5bdb\uff0c \u5e73\u585a\u7d14\u4e00\uff0c\u8f9b\u5d8b\u535a\uff0c\u795e\u7530\u5553\u6cbb\uff0c\u53e4\u6797\u5fb9  \/p.37
    Selective Thermal Neutron Capture Therapy of Malignant Melanoma: Treatment of Human Cases \/ Yutaka Mishima, Chihiro Honda, Masahiro Shiono, Nobutoshi Wadabayashi, Masamitsu Ichihashi, Hidefumi Obara\u3001Hiroshi Fukuda, Junichi Hiratsuka\u3001HiroshiKarashima, Keiji Kanda and Tooru Kobayashi<\/li>\n\n\n\n
  7. \u60aa\u6027\u9ed2\u8272\u816b\u306e\u7279\u7570\u7684\u4ee3\u8b1d\u6d3b\u6027\u306b\u3088\u308b\u71b1\u4e2d\u6027\u5b50\u6355\u6349\u7642\u6cd5 \/\u4e09\u5d8b\u8c4a\uff0c\u5e02\u6a4b\u6b63\u5149\uff0c\u672c\u7530\u5343\u535a\uff0c\u5869\u91ce\u6b63\u535a\uff0c\u5c0f\u6751\u6566\u5b50\uff0c\u548c\u7530\u6797\u5c55\u5e74\uff0c\u4e2d\u5ddd\u4fca\u592b  \/p.49
    Selective Thermal Nuetron Capture Therapy of Malignant Melanoma Using Its  Specific Metablic Activities \/ Yutaka Mishima, Masamitsu Ichihashi, Chihiro Honda, Masahiro Shiono, Atsuko Komura, Nobutoshi Wadabayashi and Toshia Nakagawa<\/li>\n\n\n\n
  8. 8. Tissue Distribution of Para-Boronophenylalanine Administered Orally as a Cyclodextrin Inclusion Complex to Melanoma-Bearing Hamsters\/ Hisakatsu Hatanaka, Fusao Komada, Masahiro Shiono, Yutaka Mishima and Katsuhiko Okumura  \/p.56<\/li>\n\n\n\n
  9. 9. \u30db\u30a6\u7d20\u71b1\u4e2d\u6027\u5b50\u6355\u6349\u7642\u6cd5\u306e\u305f\u3081\u306e10<\/sup>B\u5316\u5408\u7269\u306e\u816b\u760d\u7d30\u80de\u89aa\u548c\u6027\u306b\u95a2\u3059\u308b\u7814\u7a76-10<\/sup>B1<\/sub>-Paraboronophenylalanine\u306e\u60aa\u6027\u9ed2\u8272\u816b\u7d30\u80de\u7279\u7570\u7684\u96c6\u7a4d\u6027\u306e\u6a5f\u5e8f\u306b\u3064\u3044\u3066\u4e00\/ \u5869\u91ce\u6b63\u535a\uff0c\u829d\u7530\u5b5d\u4e00\uff0c\u5e02\u6a4b\u6b63\u5149\uff0c\u4e09\u5d8b\u8c4a  \/p.59
    The Mechanism of the Selective Affinity of 10<\/sup>B1<\/sub>-Paraboronophenylalanine for Malignant Melanoma \/ Masahiro Shiono, Takakazu Shibata, Masamitsu Ichihashi and Yutaka Mishima<\/li>\n\n\n\n
  10. Deuteriation Trials for Neutron Capture Therapy of Deep-Seated Melanoma Lesions \/ Chihiro Honda, Masahiro Shiono, Nobutoshi Wadabayashi, Masamitsu Ichihashi, Yutaka Mishima, Kazuo Yoshino, Tooru Kobayashi\u3001KeijiKanda and Hiroshi Karashima  \/p.66<\/li>\n\n\n\n
  11. Experiences of BNCT Using the KUR \/ Keiji Kanda, Tooru Kobayashi, Keizo Akuta and Koji Ono  \/p.70<\/li>\n\n\n\n
  12. Procedures for the Medical Application of Research Reactors \/ Keiji Kanda  \/p.75<\/li>\n\n\n\n
  13. \u533b\u7642\u7528\u539f\u5b50\u7089\/ \u795e\u7530\u5553\u6cbb\uff0c\u4e09\u5d8b\u8c4a  \/p.79
    Medical Reactor \/ Keiji Kanda and Yutaka Mishirna<\/li>\n\n\n\n
  14. Study on Remodeling the Heavy Water Facility of the Kyoto University Reactor for Neutron Capture Therapy from the Concept of Neutron Energy Spectrum Control \/ Tooru Kobayashi\u3001YoshinoriSakurai and Keiji Kanda  \/p.87<\/li>\n\n\n\n
  15. Analytical Dose Calculation in Cell Nucleus from Spherical 10<\/sup>B Containing Region and a Concept of RBE for Neutron Capture Therapy\/ Tooru Kobayashi and Keiji Kanda  \/p.91<\/li>\n\n\n\n
  16. \u533b\u5b66\u7269\u7406\u5b66\u304b\u3089\u307f\u305f\u4e2d\u6027\u5b50\u6355\u6349\u7642\u6cd5\u306e\u73fe\u72b6\u3068\u5c06\u6765\/\u53e4\u6797\u5fb9\uff0c\u795e\u7530\u5553\u6cbb  \/p.95
    The Status and the Future of Medical Physics for Neutron Capture Therapy\/ Tooru Kobayashi and Keiji Kanda<\/li>\n\n\n\n
  17. \u533b\u7642\u7167\u5c04\u3092\u4e3b\u76ee\u7684\u306b\u3057\u305f\u91cd\u6c34\u71b1\u4e2d\u6027\u5b50\u8a2d\u5099\u6539\u9020\u691c\u8a0e\/ \u53e4\u6797\u5fb9\uff0c\u685c\u4e95\u826f\u61b2\uff0c\u795e\u7530\u5553\u6cbb  \/p.98
    Study on Remodeling of the Heavy Water Facility of the Kyoto University Reactor Mainly from the Viewpoint of Neutron Capture Therapy \/ Tooru Kobayashi, Yoshinori Sakurai and Keiji Kanda<\/li>\n\n\n\n
  18. BNCT \u306b\u304a\u3051\u308b\u751f\u4f53\u5185\u6df1\u90e8\u3067\u306e\u71b1\u4e2d\u6027\u5b50\u7dda\u91cf\u7387\u6539\u5584\u306e\u8a08\u7b97\u53ca\u3073\u5b9f\u9a13\/ \u306b\u3088\u308b\u691c\u8a0e \/ \u685c\u4e95\u826f\u61b2\uff0c\u53e4\u6797\u5fb9\uff0c\u5c0f\u91ce\u5149\u4e00\uff0c \u4f50\u85e4\u5b5d\u53f8\uff0c \u795e\u7530\u5553\u6cbb  \/p.106
    Improvement of Thermal Neutron Fluence at the Deeper Part in Tissue for BNCT: Simulation Calculation and Phantom Experiment \/ Yoshinori Sakurai, Tooru Kobayashi\u3001Koichi Ono, Takashi Sato and Keiji Kanda<\/li>\n\n\n\n
  19. Improvement of Thermal Neutron Fluence for BNCT Treatment of Deep-Seated Tumors : Simulation Calculation and Phantom Experiments\/ Yoshinori Sakurai\u3001Tooru Kobayashi, Koichi Ono, Takashi Sato and Keiji Kanda   \/p.114<\/li>\n\n\n\n
  20. \u4e2d\u6027\u5b50\u6355\u6349\u7642\u6cd5\u306b\u304a\u3051\u308b\u751f\u4f53\u8868\u9762\u8fd1\u508d\u3067\u306e\u71b1\u4e2d\u6027\u5b50\u7dda\u91cf\u6e2c\u5b9a\u304a\u3088\u3073\u305d\u306e\u8a55\u4fa1\u4e26\u3073\u306b\u751f\u4f53\u5185\u6df1\u90e8\u3067\u306e\u71b1\u4e2d\u6027\u5b50\u7dda\u91cf\u5206\u5e03\u306e\u6539\u5584\u306b\u95a2\u3059\u308b\u7814\u7a76\/ \u685c\u4e95\u826f\u61b2\uff0c\u53e4\u6797\u5fb9\uff0c\u795e\u7530\u5553\u6cbb  \/p.119
    A Study on Measurement and Estimation of Thermal Neutron Dose near the Surface of Human Body, and Improvement of Thermal-Neutron Dose Distribution at the Deeper Part for Neutron Capture Therapy \/ Yoshinori Sakurai, Tooru Kobayashi and Keiji Kanda<\/li>\n\n\n\n
  21. \u71b1\u4e2d\u6027\u5b50\u675f\u6e2c\u5b9a\u306b\u304a\u3051\u308b\u751f\u4f53\u8868\u9762\u8fd1\u508d\u3067\u306e\u91d1\u7dda\u304a\u3088\u3073\u91d1\u7b94\u306e\u81ea\u5df1\u906e\u853d\u56e0\u5b50\u306e\u691c\u8a0e \/\u685c\u4e95\u826f\u61b2\uff0c\u666f\u5e73\u514b\u5fd7\uff0c\u53e4\u6797\u5fb9\uff0c\u795e\u7530\u5553\u6cbb  \/p.139
    A Study on Self-Shielding Factor near the Surface of Human Body Using Gold Wire and Foil for Thermal Neutron Flux Measurement \/ Yoshinori Sakurai, Katsushi Kagehira, Tooru Kobayashi and Keiji Kanda<\/li>\n\n\n\n
  22. Reevaluation of Thermal Neutron Field of the KUR Heavy Water Facility for Biomedical Uses : Optimization of Bismuth, Heavy Water and Graphite Layers \/ Yoshinori Sakurai, Shusuke Fujihara, Tooru Kobayashi and Keiji Kanda  \/p.147<\/li>\n\n\n\n
  23. Analysis for Remodeling of the KUR Heavy Water Facility for Biomedical Uses : Shutter System for Continuous Use of the Facility under 5MW Operation \/ Yoshinori Sakurai\u3001Tooru Kobayashi and Keiji Kanda  \/p.152<\/li>\n\n\n\n
  24. Evaluation of Neutron Irradiation Fields for BNCT by Using \/ Otohiko Aizawa  \/p.163<\/li>\n\n\n\n
  25. Determination of p-Boronophenylalanine in Biological Tissues with High Performance Liquid Chromatography\/ Kazuo Yoshino, Tomaro Takasoh, Hisakatsu Hatanaka, Fusao Komada\u3001Katsuhiko Okumura, Yutaka Mishima, Chihiro Honda and Yoshihiro Mori  \/p.168<\/li>\n\n\n\n
  26. Relation between Structures of p-Boronophenylalanine Related Compounds and Their Usefulness for Boron Neutron Capture Therapy\/ Hidetake Kakihana, Kazuo Yoshino and Yoshihiro Mori  \/p.175<\/li>\n\n\n\n
  27. Capture of p-Boronophenylalanine by Melanin-Related Compounds: Complex Formation of p-Boronophenylalanine with L-Dopa \/ Kazuo Yoshino\u3001Takanobu Maruyama, Yoshihiro Mori, Hidetake Kakihana and Yutaka Mishima  \/p.179<\/li>\n\n\n\n
  28. Proposed Mechanism of Capture and Release of p-Boronophenyl-alanine through Melanoma Cells : Chemical Behaviour of p-Boronophenylalanine- Fructose Complex in L-Dopa Solution \/ Kazuo Yoshino, Hidetake Kakihana\u3001YoshihiroMori, Naruyuki Torii, Hiroaki Takahashi and Yutaka Mishima  \/p.183<\/li>\n\n\n\n
  29. Synthesis of o-and m-Boronophenylalanine \/ Kazuo Yoshino\u3001Takanobu Maruyama, Hiroaki Takahashi, Yoshihiro Mori\u3001Hidetake Kakihana, Yutaka Mishima, Masamitsu Ichihashi, Chihiro Honda and Masahiro Shiono  \/p.187<\/li>\n\n\n\n
  30. A New Water-Soluble p-Boronophenylalanine Derivative for Neutron Capture Therapy \/ Hisao Nemoto, Satoshi Iwamoto\u3001Hiroyuki Nakamura and Yoshinori Yamamoto  \/p.191<\/li>\n\n\n\n
  31. Preliminary Studies on the Preparation of Boronated Monoclonal Antibodies Intended for Neutron Capture Therapy \/ Toshia Nakagawa, Yutaka Mishima, Kazuhito Hayashibe and Masamitsu Ichihashi  \/p.191<\/li>\n\n\n\n
  32. Optimization of Neutron Fluence and Timing of Irradiation for the Treatment of Malignant Melanoma by Boron Neutron Capture Therapy Using 10<\/sup>B-Paraboronophenylalanine \/ Hiroshi Fukuda, Junichi Hiratsuka, Chihiro Honda, Tooru kobayashi, Kazuo Yoshino, Yoshinao Abe, Jutaro Takahashi, Masahiro Shiono, Hiroshi Karashima, Keiji Kanda, Masamitsu Ichihashi and Yutaka Mishima  \/p.212<\/li>\n\n\n\n
  33. \u4e2d\u6027\u5b50\u6355\u6349\u7642\u6cd5\u306e\u73fe\u72b6(3)-\uff0a\u30db\u30a6\u7d20\u4e2d\u6027\u5b50\u6355\u6349\u6cbb\u7642\u306e\u73fe\u72b6\u3068\u554f\u984c\u70b9\/ \u798f\u7530\u5bdb\u00a0 \/p.221
    Present Status of Neutron Capture Therapy of Cancer (3) : Present Status and Problems of Boron Neutron Capture Therapy of Malignant Melanoma \/ Hiroshi Fukuda \/p.221<\/li>\n\n\n\n
  34. \u653e\u5c04\u7dda\u7642\u6cd5\uff0d\u9ed2\u8272\u816b\u9000\u7e2e\u52b9\u679c\uff0d\u798f\u7530\u5bdb\u3001\u6052\u5143\u535a  \/p.223
    Radiotherapy of Malignant Melanoma :Radiosensitivity and Local Control \/Hiroshi Fukuda and Hiroshi Tsunemoto<\/li>\n\n\n\n
  35. Thermal Neutron Capture Therapy Using 10<\/sup>B1<\/sub>-BPA: Inducement of Marked Lethal Effect on Melanoma Cells Irrespective of X-ray \/ Sensitivity \/ Masamitsu Ichihashi, Hiroshi Utsumi, Hidekazu Tsukamoto, Yutaka Mishima and Tooru Kobayashi  \/p.22<\/li>\n\n\n\n
  36. \u71b1\u4e2d\u6027\u5b50\u6355\u6349\u7642\u6cd5\u3092\u65bd\u884c\u3057\u305f\u60aa\u6027\u9ed2\u8272\u816b\u75c7\u4f8b\u306e\u5438\u53ce\u7dda\u91cf\u5206\u5e03\u3068\u5c40\u6240\u52b9\u679c \/\u5e73\u585a\u7d14\u4e00\uff0c\u798f\u7530\u5bdb\uff0c\u53e4\u6797\u5fb9\uff0c\u795e\u7530\u5553\u6cbb\uff0c\u5e02\u6a4b\u6b63\u5149\uff0c\u4e09\u5d8b\u8c4a  \/p.235
    The Local Response and the Absorbed Dose in a Human Melanoma Treated by Neutron Capture Therapy \/ Junichi Hiratsuka, Hiroshi Fukuda, Tooru Kobayashi, Keiji Kanda, Masamitsu Ichihashi and Yutaka Mishima<\/li>\n\n\n\n
  37. \u60aa\u6027\u9ed2\u8272\u816b\u306b\u5bfe\u3059\u308b\u71b1\u4e2d\u6027\u5b50\u6355\u6349\u7642\u6cd5\u306e\u6cbb\u7642\u52b9\u679c\u6bd4 \/ \u5e73\u585a\u7d14\u4e00\uff0c\u798f\u7530\u5bdb\uff0c\u53e4\u6797\u5fb9\uff0c\u4e09\u5d8b\u8c4a  \/p.245
    Therapeutic Gain Factor of Thermal Neutron Capture Therapy of Malignant Melanoma \/ Junichi Hiratsuka, Hiroshi Fukuda, Tooru Kobayashi and Yutaka Mishima<\/li>\n\n\n\n
  38. A Unique in Vivo Assessment of 4-[10<\/sup>B] borono-L-Phenylalanine in Tumor Tissues for Boron Neutron Capture Therapy of Malignant Melanomas Using Positron Emission Tomography and 4-Borono-2-[18<\/sup>F] Fluoro-L-Phenylalanine\/ Kiichi Ishiwata, Masahiro Shiono, Kazuo Kubota, Kazuo Yoshino, Jun Hatazawa, Tatsuo Ido, Chihiro Honda, Masamitsu Ichihashi and Yutaka Mishima  \/p.251<\/li>\n\n\n\n
  39. 18F-1\u00b0B-L-BPA\u306b\u3088\u308b\u60aa\u6027\u9ed2\u8272\u816b\u306e\u753b\u50cf\u5316\u30fc\u30dd\u30b8\u30c8\u30ed\u30f3CT\u306b\u3088\u308b\u751f\u5316\u5b66\u7684\u8a55\u4fa1\u3068BNCT\u3078\u306e\u5fdc\u7528\u4e00 \/\u4eca\u5800\u826f\u592b\uff0c\u4e09\u5d8b\u8c4a\uff0c\u672c\u7530\u5343\u535a\uff0c\u4e0a\u7530\u8056\uff0c\u5800\u4e95\u5747\uff0c\u8107\u7530\u54e1\u7537\uff0c\u85e4\u4e95\u4eae\uff0c\u4e95\u6238\u9054\u96c4\u00a0 \/p.261
    Imaging and Metabolic Evaluation of Malignant Melanoma by Positron Emission Tomography using 18<\/sup>F-10<\/sup>B-L-BPA \/ Yoshio Imahori, Yutaka Mishima, Chihiro Honda, Satoshi Ueda, Hitoshi Horii, Kazuo Wakita, Ryou Fujii and Tatsuo Ido<\/li>\n<\/ol>\n\n\n\n

    <\/p>\n","protected":false},"excerpt":{"rendered":"

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