{"id":4634,"date":"2026-06-01T09:07:15","date_gmt":"2026-06-01T00:07:15","guid":{"rendered":"https:\/\/adm.rri.kyoto-u.ac.jp\/pub\/?p=4634"},"modified":"2026-06-01T09:07:15","modified_gmt":"2026-06-01T00:07:15","slug":"kurri-tr-390","status":"publish","type":"post","link":"https:\/\/adm.rri.kyoto-u.ac.jp\/pub\/kurri-tr-390\/","title":{"rendered":"KURRI-TR-390"},"content":{"rendered":"\n
\"\"<\/figure>\n\n\n\n

\u4e2d\u6027\u5b50\u6355\u6349\u7642\u6cd5\u306e\u6539\u5584\u3068\u9069\u5fdc\u62e1\u5927\u306e\u305f\u3081\u306e\u57fa\u790e\u7684\u81e8\u5e8a\u7684\u7814\u7a76
Basic and Clinical Researches for the Development of Neutron Capture Therapy<\/p>\n\n\n\n

1994\u5e743\u6708\u3000(March, 1994)
\u7de8\u96c6\uff1a\u83ca\u6c60 \u6674\u5f66
Edited by\uff1a Haruhiko Kikuchi<\/p>\n\n\n\n

\u76ee\u6b21<\/strong><\/p>\n\n\n\n

\u2160. \u5e8f\u8a00\uff08\u2170\uff09<\/p>\n\n\n\n

\u2161. \u7814\u7a76\u767a\u8868\uff08\u2172\uff09<\/p>\n\n\n\n

\u751f\u4f53\u6d3b\u6027\u3092\u6709\u3059\u308bB-10\u30ad\u30e3\u30ea\u30a2\u306e\u5316\u5b66\u5408\u6210\u3068BNCT\u3078\u306e\u5fdc\u7528\/\uff08\u6771\u5317\u5927\u5b66\u7406\u5b66\u90e8\u5316\u5b66\u7b2c2\u5b66\u79d1\uff09\u5c71\u672c\u5609\u5247  \/p.1<\/p>\n\n\n\n

\u4e2d\u6027\u5b50\u6355\u6349\u6cbb\u7642\u306e\u305f\u3081\u306e10<\/sup>B\u30ad\u30e3\u30ea\u30a2\u30fc\u306e\u5206\u5b50\u8a2d\u8a08\u3068\u5408\u6210\/\uff08\u6771\u5317\u5927\u7406\uff09\u5c71\u672c\u5609\u5247  \/p.3<\/p>\n\n\n\n

\u6838\u9178\u5869\u57fa\u3092\u542b\u3080\u30ab\u30eb\u30dc\u30e9\u30f3\u306e\u5408\u6210\uff0e\u304c\u3093\u7d30\u80de\u306b\u5bfe\u3059\u308b\u4e88\u60f3\u4ee5\u4e0a\u306e\u9ad8\u3044\u7d30\u80de\u6bd2\u6027\/\uff08\u6771\u5317\u5927\u7406\uff09\u5c71\u672c\u5609\u5247\u3001\u4e16\u53e4\u654f\u4e5f\u3001\u4e2d\u6751\u6d69\u4e4b\u3001\u6839\u672c\u5c1a\u592b\uff08\u6771\u5317\u5927\u85ac\uff09\u5317\u689d\u535a\u53f2\u3001\u5411\u4e95\u76f4\u4eba\u3001\u6a4b\u672c\u5609\u5e78  \/p.7<\/p>\n\n\n\n

\u30ab\u30b9\u30b1\u30fc\u30c9\u578b\u30dd\u30ea\u30aa\u30fc\u30eb\uff0e\u30db\u30a6\u7d20\u4e2d\u6027\u5b50\u6355\u6349\u6cbb\u7642\u306e\u305f\u3081\u306e\u6c34\u6eb6\u6027\u30ab\u30eb\u30dc\u30e9\u30f3\u8a98\u5c0e\u4f53\/\uff08\u6771\u5317\u5927\u7406\uff09\u6839\u672c\u5c1a\u592bJ. Gerald Wilson \u4e2d\u6751\u6d69\u4e4b\u3001\u5c71\u672c\u5609\u5247  \/p.9<\/p>\n\n\n\n

\u30db\u30a6\u7d20\u4e2d\u6027\u5b50\u6355\u6349\u6cbb\u7642\u306e\u30db\u30a6\u7d20\u904b\u642c\u4f53\u306e\u5408\u6210\u53ca\u3073\u5206\u5b50\u8a2d\u8a08\/\uff08\u6771\u5317\u5927\u7406\uff09\u5c71\u672c\u5609\u5247\u3001\u6839\u672c\u5c1a\u592b\u3001\u4e16\u53e4\u654f\u4e5f\u3001\u9ad8\u677e\u8061\u3001\u6804\u98a8\u5149  \/p.10<\/p>\n\n\n\n

\u6838\u9178\u5869\u57fa\u3092\u542b\u3080\u30ab\u30eb\u30dc\u30e9\u30f3\u306e\u5408\u6210\/\uff08\u6771\u5317\u5927\u7406\uff09\u5c71\u672c\u5609\u5247\u3001\u4e16\u53e4\u654f\u4e5f\u3001\u4e2d\u6751\u6d69\u4e4b\u3001\u6839\u672c\u5c1a\u592b  \/p.14<\/p>\n\n\n\n

\u4e2d\u6027\u5b50\u6355\u6349\u6cbb\u7642\u306e\u305f\u3081\u306e\u65b0\u898f\u6c34\u6eb6\u6027\u30d1\u30e9\u30dc\u30ed\u30ce\u30d5\u30a7\u30cb\u30eb\u30a2\u30e9\u30cb\u30f3\u8a98\u5c0e\u4f53\/\uff08\u6771\u5317\u5927\u7406\uff09\u6839\u672c\u5c1a\u592b\u3001\u5ca9\u672c\u8061\u3001\u4e2d\u6751\u6d69\u4e4b\u3001\u5c71\u672c\u5609\u5247  \/p.20<\/p>\n\n\n\n

\u304c\u3093\u7d30\u80de\u5b58\u5728\u4e0b\u3067\u306e\u30db\u30a6\u7d20\u5316\u5408\u7269\u306e11<\/sup>BNMR\/\uff08\u6771\u5317\u5927\u7406\uff09\u5c71\u672c\u5609\u5247\u3001\u9ad8\u677e\u8061\u3001\u4e2d\u6751\u6d69\u4e4b  \/p.24<\/p>\n\n\n\n

\u30a2\u30df\u30c9\u9285\u53cd\u5fdc\u5264\u3092\u7528\u3044\u308b\u30a8\u30dd\u30ad\u30b7\u30c9\u306e\u4f4d\u7f6e\u53ca\u3073\u7acb\u4f53\u9078\u629e\u7684\u958b\u74b0\u53cd\u5fdc\/\uff08\u6771\u5317\u5927\u7406\uff09\u5c71\u672c\u5609\u5247\u3001\u6d45\u5c3e\u76f4\u6a39\u3001\u76ee\u9ed2\u6b63\u898f\u3001\u585a\u7530\u76f4\u6587\u3001\u6839\u672c\u5c1a\u592b\u3001\u8c9e\u983c\u76f4\u6a39\u3001J. Gerald Wilson\u3001\u4e2d\u6751\u6d69\u4e4b  \/p.27<\/p>\n\n\n\n

1\uff0d\u30ab\u30eb\u30dc\u30e9\u30cb\u30eb\uff0d3\uff0d(2\uff0d\u30e1\u30c1\u30eb\u30a2\u30b8\u30ea\u30b8\u30ce\uff09\uff0d2\uff0d\u30d7\u30ed\u30d1\u30ce\u30fc\u30eb\uff0e\u5408\u6210\u3001B-16\u30e1\u30e9\u30ce\u30fc\u30de\u306b\u3088\u308b\u9078\u629e\u7684\u53d6\u308a\u8fbc\u307f\uff0c\u304a\u3088\u3073\u304c\u3093\u7d30\u80de\u306b\u5bfe\u3059\u308b\u9078\u629e\u7684\u7d30\u80de\u6bd2\u6027\/\uff08\u6771\u5317\u5927\u7406\uff09\u5c71\u672c\u5609\u5247\u3001\u4e2d\u6751\u6d69\u4e4b  \/p.30<\/p>\n\n\n\n

\u4e2d\u6027\u5b50\u6355\u6349\u7642\u6cd5\u6539\u5584\u306e\u305f\u3081\u306e\u65b0\u3057\u3044\u816b\u760d\u7279\u7570\u7684\u5316\u5408\u7269\u306e\u958b\u767a\u306b\u95a2\u3059\u308b\u57fa\u790e\u7684\u7814\u7a76\/ \uff08\u7b51\u6ce2\u5927\u5b66\u81e8\u5e8a\u533b\u5b66\u7cfb\u8133\u795e\u7d4c\u5916\u79d1\uff09\u677e\u6751\u660e\u3001\u4e2d\u5ddd\u90a6\u592b\u3001\u5409\u4e95\u8f3f\u5fd7\u5f66\u3001\u80fd\u52e2\u5fe0\u7537  \/p.33<\/p>\n\n\n\n

\u30dd\u30b8\u30c8\u30ed\u30f3\u65ad\u5c64\u6cd5\u306b\u3088\u308b\u653e\u5c04\u7dda\u8133\u969c\u5bb3\u306e\u8a55\u4fa1\u306b\u95a2\u3059\u308b\u57fa\u790e\u7814\u7a76\/\uff08\u6771\u5317\u5927\u5b66\u52a0\u9f62\u533b\u5b66\u7814\u7a76\u6240\u6a5f\u80fd\u753b\u50cf\u533b\u5b66\u7814\u7a76\u5206\u91ce\uff09\u963f\u90e8\u7531\u76f4\u3001\u798f\u7530\u5bdb\u3001\u5c0f\u91ce\u4fee\u4e00\u3001\u9ad8\u6a4b\u5bff\u592a\u90ce\u3001\u4f50\u85e4\u591a\u667a\u96c4  \/p.44<\/p>\n\n\n\n

\u30db\u30a6\u7d20\u5316\u91d1\u5c5e\u30dd\u30eb\u30d5\u30a3\u30ea\u30f3\u3092\u7528\u3044\u305f\u30db\u30a6\u7d20\u71b1\u4e2d\u6027\u5b50\u6355\u6349\u7642\u6cd5\u306b\u3088\u308b\u30de\u30a6\u30b9\u60aa\u6027\u9ed2\u8272\u816b\u3068\u8840\u7ba1\u8089\u816b\u7d30\u80de\u306b\u5bfe\u3059\u308b\u81f4\u6b7b\u52b9\u679c\/ \uff08\u795e\u6238\u5927\u5b66\u533b\u5b66\u90e8\u76ae\u819a\u79d1\u5b66\u6559\u5ba4\uff09\u5c71\u7530\u81f3\u5f66\u3001\u5e02\u6a4b\u6b63\u5149\uff08\u30ab\u30ea\u30d5\u30a9\u30eb\u30cb\u30a2\u5927\u5b66\u85ac\u7406\u79d1\u5b66\u6559\u5ba4\uff09 Stephen B. Kahl\uff08\u4eac\u90fd\u5927\u5b66\u533b\u5b66\u90e8\u76ae\u819a\u79d1\u5b66\u6559\u5ba4\uff09\u6238\u7530\u61b2\u4e00  \/p.49<\/p>\n\n\n\n

\u30d2\u30c8\u773c\u90e8\u60aa\u6027\u9ed2\u8272\u816b\u306b\u304a\u3051\u308b10<\/sup>B1<\/sub>-BPA \u306e\u9078\u629e\u7684\u96c6\u7a4d\u6027~\u4e2d\u6027\u5b50\u6355\u6349\u7642\u6cd5\u306e\u305f\u3081\u306b\u4e00\/ \uff08\u795e\u6238\u5927\u5b66\u533b\u5b66\u90e8\u76ae\u819a\u79d1\u5b66\u6559\u5ba4\uff09\u548c\u7530\u6797\u5c55\u5e74\u3001\u5e02\u6a4b\u6b63\u5149\uff08\u5175\u5eab\u770c\u7acb\u52a0\u53e4\u5ddd\u75c5\u9662\uff09\u672c\u7530\u5343\u535a\uff08\u4e09\u5d8b\u76ae\u819a\u79d1\u5b66\u7814\u7a76\u6240\uff09\u4e09\u5d8b\u8c4a  \/p.57<\/p>\n\n\n\n

\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u4e2d\u6027\u5b50\u6355\u6349\u7642\u6cd5\u306e\u57fa\u790e\u7684\u7814\u7a76\/ \uff08\u56fd\u7acb\u304c\u3093\u30bb\u30f3\u30bf\u30fc\u4e2d\u592e\u75c5\u9662\u7b2c\u4e00\u5916\u6765\u90e8\uff09\u79cb\u6839\u5eb7\u4e4b  \/p.67<\/p>\n\n\n\n

\u30cf\u30a4\u30d1\u30fc\u71b1\u4e2d\u6027\u5b50\u306e\u4e2d\u6027\u5b50\u6355\u6349\u7642\u6cd5\u3078\u306e\u5fdc\u7528\/\uff08\u4eac\u90fd\u5927\u5b66\u539f\u5b50\u7089\u5b9f\u9a13\u6240\uff09\u795e\u7530\u5553\u6cbb\u3001\u53e4\u6797\u5fb9\u3001\u685c\u4e95\u826f\u61b2  \/p.79<\/p>\n\n\n\n

\u71b1\u4e2d\u6027\u5b50\u3068\u71b1\u5916\u4e2d\u6027\u5b50\u306e\u6df7\u5728\u5834\u306eNCT\u306b\u304a\u3051\u308b\u6df1\u90e8\u7dda\u91cf\u5206\u5e03\/\uff08\u4eac\u90fd\u5927\u5b66\u539f\u5b50\u7089\u5b9f\u9a13\u6240\uff09\u53e4\u6797\u5fb9\u3001\u685c\u4e95\u826f\u61b2\u3001\u795e\u7530\u5553\u6cbb  \/p.81<\/p>\n\n\n\n

10<\/sup>B\u5316\u5408\u7269\u306e\u4e0d\u5747\u4e00\u5206\u5e03\uff08\u7d30\u80de\u30ec\u30d9\u30eb\uff09\u306e\u653e\u5c04\u7dda\u751f\u7269\u5b66\u7684\u691c\u51fa\/\uff08\u4eac\u5927\u533b\u5b66\u90e8\u653e\u5c04\u7dda\u79d1\uff09\u963f\u90e8\u5149\u5e78\uff08\u4eac\u5927\u539f\u5b50\u7089\u5b9f\u9a13\u6240\uff09\u5c0f\u91ce\u516c\u4e8c\u3001\u5897\u6c38\u614e\u4e00\u90ce\u3001\u9ad8\u57a3\u653f\u96c4\u3001\u6728\u68a8\u53cb\u5b50  \/p.87<\/p>\n\n\n\n

BNCT\u306e\u6539\u5584\uff0c\u5b9f\u65bd\u3068\u7814\u7a76\/\uff08\u4eac\u90fd\u5927\u5b66\u533b\u5b66\u90e8\u8133\u795e\u7d4c\u5916\u79d1\uff09\u83ca\u6c60\u6674\u5f66\u3001\u7e54\u7530\u7965\u53f2\u3001\u5bae\u6b66\u4f38\u4e00\u3001\u9ad8\u6a4b\u6f64\u3001\u5f35\u9707\u83ef\uff08\u4eac\u90fd\u5927\u5b66\u539f\u5b50\u7089\u5b9f\u9a13\u6240\uff09\u9ad8\u57a3\u653f\u96c4  \/p.91<\/p>\n\n\n\n

\u8133\u816b\u760d\u306b\u5bfe\u3059\u308b\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u4e2d\u6027\u5b50\u6355\u6349\u7642\u6cd5\u4e00\u751f\u7269\u5b66\u7684\u89b3\u70b9\u3088\u308a\u4e00\/\uff08\u4eac\u90fd\u5927\u5b66\u533b\u5b66\u90e8\u8133\u795e\u7d4c\u5916\u79d1\uff09\u9ad8\u57a3\u653f\u96c4\u3001\u7e54\u7530\u7965\u53f2\u3001\u677e\u672c\u614e\u4eba\u3001\u83ca\u6c60\u6674\u5f66\uff08\u4eac\u90fd\u5927\u5b66\u539f\u5b50\u7089\u5b9f\u9a13\u6240\uff09\u53e4\u6797\u5fb9\u3001\u795e\u7530\u5553\u6cbb\u3001\u4e0a\u91ce\u967d\u91cc\u7d75  \/p.92<\/p>\n\n\n\n

\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u4e2d\u6027\u5b50\u6355\u6349\u7642\u6cd5\u306e\u53ef\u80fd\u6027\u306b\u3064\u3044\u3066\uff08\u4eac\u90fd\u5927\u5b66\u533b\u5b66\u90e8\u8133\u795e\u7d4c\u5916\u79d1\uff09\u7e54\u7530\u7965\u53f2\u3001\u9ad8\u57a3\u653f\u96c4  \/p.98<\/p>\n\n\n\n

\u8133\u816b\u760d\u306b\u5bfe\u3059\u308b\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u4e2d\u6027\u5b50\u6355\u6349\u7642\u6cd5\u2014 in vitro\u7814\u7a76\u4e00\/\uff08\u4eac\u90fd\u5927\u5b66\u533b\u5b66\u90e8\u8133\u795e\u7d4c\u5916\u79d1\uff09\u9ad8\u57a3\u653f\u96c4\u3001\u7e54\u7530\u7965\u53f2\u3001\u83ca\u6c60\u6674\u5f66\uff08\u4eac\u90fd\u5927\u5b66\u539f\u5b50\u7089\u5b9f\u9a13\u6240\uff09\u53e4\u6797\u5fb9\u3001\u795e\u7530\u5553\u6cbb\u3001\u4e0a\u91ce\u967d\u91cc  \/p.99<\/p>\n\n\n\n

\u8133\u816b\u760d\u306b\u5bfe\u3059\u308b\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u4e2d\u6027\u5b50\u6355\u6349\u7642\u6cd5\/\uff08\u4eac\u90fd\u5927\u5b66\u533b\u5b66\u90e8\u8133\u795e\u7d4c\u5916\u79d1\uff09\u7e54\u7530\u7965\u53f2\u3001\u9ad8\u57a3\u653f\u96c4\u3001\u5bae\u6b66\u4f38\u4e00\u3001\u83ca\u6c60\u6674\u5f66  \/p.101<\/p>\n\n\n\n

\u8133\u816b\u760d\u306b\u5bfe\u3059\u308b\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u4e2d\u6027\u5b50\u6355\u6349\u7642\u6cd5\u306b\u3088\u308b\u6bba\u816b\u760d\u52b9\u679c\/\uff08\u4eac\u90fd\u5927\u5b66\u533b\u5b66\u90e8\u8133\u795e\u7d4c\u5916\u79d1\uff09\u9ad8\u57a3\u653f\u96c4\u3001\u7e54\u7530\u7965\u53f2\u3001\u5bae\u6b66\u4f38\u4e00\u3001\u83ca\u6c60\u6674\u5f66\uff08\u4eac\u90fd\u5927\u5b66\u539f\u5b50\u7089\u5b9f\u9a13\u6240\uff09\u53e4\u6797\u5fb9\u3001\u795e\u7530\u5553\u6cbb\u3001\u4e0a\u91ce\u967d\u91cc  \/p.104<\/p>\n\n\n\n

\u60aa\u6027\u8133\u816b\u760d\u306b\u5bfe\u3059\u308bGADOLINIUM\u5fdc\u7528\u306b\u3088\u308b\u4e2d\u6027\u5b50\u6355\u6349\u7642\u6cd5\u306e\u7814\u7a76\/\uff08\u4eac\u90fd\u5927\u5b66\u533b\u5b66\u90e8\u8133\u795e\u7d4c\u5916\u79d1\uff09\u7e54\u7530\u7965\u53f2\u3001\u9ad8\u57a3\u653f\u96c4\u3001\u5bae\u6b66\u4f38\u4e00\u3001\u83ca\u6c60\u6674\u5f66  \/p.108<\/p>\n\n\n\n

\u8133\u816b\u760d\u306e\u4e2d\u6027\u5b50\u6355\u6349\u7642\u6cd5\u57fa\u790e\u7814\u7a76\u4e00\u65b0\u3057\u3044\u787c\u7d20\u5316\u5408\u7269\u306e\u958b\u767a \u30a2\u30eb\u30d5\u30a1\u30fc\u30fb\u30aa\u30fc\u30c8\u30e9\u30b8\u30aa\u30b0\u30e9\u30d5\u30a3\u30fc\u306b\u3088\u308b\u7d44\u7e54\u53ca\u3073\u7d30\u80de\u5185\u787c\u7d20\u5206\u5e03\u306e\u5b9a\u91cf\u7684\u89e3\u6790\/\uff08\u4eac\u90fd\u5927\u5b66\u533b\u5b66\u90e8\u8133\u795e\u7d4c\u5916\u79d1\uff09\u9ad8\u57a3\u653f\u96c4\u3001\u7e54\u7530\u7965\u53f2\u3001\u83ca\u6c60\u6674\u5f66\uff08\u7acb\u6559\u5927\u5b66\u539f\u5b50\u529b\u7814\u7a76\u6240\uff09\u6797\u8129\u5e73\u3001\u539f\u6ca2\u9032\u3001\u6238\u6751\u5065\u5150  \/p.114<\/p>\n\n\n\n

\u787c\u7d20\u4e2d\u6027\u5b50\u6355\u6349\u7642\u6cd5\u306b\u304a\u3051\u308b\u30ab\u30eb\u30dc\u30e9\u30cb\u30eb\u30a6\u30ea\u30b8\u30f3\u306e\u6bba\u816b\u760d\u52b9\u679c\/\uff08\u4eac\u90fd\u5927\u5b66\uff09\u9ad8\u57a3\u653f\u96c4\u3001\u7e54\u7530\u7965\u53f2\u3001\u5f35\u9707\u83ef\u3001\u83ca\u6c60\u6674\u5f66\uff08\u6771\u5317\u5927\u5b66\uff09\u4e2d\u6751\u6d69\u4e4b\u3001\u6839\u672c\u5c1a\u592b\u3001\u4e16\u53e4\u654f\u4e5f\u3001\u5c71\u672c\u5609\u5247 (OHIO STATE UNIV.) Albert H. Soloway\uff08\u4eac\u90fd\u5927\u5b66\u539f\u5b50\u7089\u5b9f\u9a13\u6240\uff09\u53e4\u6797\u5fb9\u795e\u7530\u5553\u6cbb  \/p.116<\/p>\n\n\n\n

\u8133\u816b\u760d\u6cbb\u7642\u306b\u304a\u3051\u308bDDS\u306e\u6709\u7528\u6027\u3068\u305d\u306e\u554f\u984c\u70b9\u306e\u89e3\u6c7a\/\uff08\u4eac\u90fd\u5927\u5b66\uff09\u7e54\u7530\u7965\u53f2\u3001\u9ad8\u6a4b\u6f64\u3001\u9ad8\u57a3\u653f\u96c4\u3001\u5927\u5c71\u61b2\u6cbb\u3001\u5bae\u6b66\u4f38\u4e00\u3001\u83ca\u6c60\u6674\u5f66  \/p.119<\/p>\n\n\n\n

\u795e\u7d4c\u81a0\u82bd\u816b\u306b\u5bfe\u3059\u308b\u787c\u7d20\u4e2d\u6027\u5b50\u6355\u6349\u7642\u6cd5\u306e\u521d\u671f\u81e8\u5e8a\u6cbb\u9a13\/\uff08\u4eac\u90fd\u5927\u5b66\uff09\u7e54\u7530\u7965\u53f2\u3001\u9ad8\u57a3\u653f\u96c4\u3001\u5f35\u9707\u83ef\u3001\u4e2d\u6d25\u6b63\u4e8c\u3001\u5bae\u6b66\u4f38\u4e00\u3001\u4e2d\u5c3e\u54f2\u3001\u83ca\u6c60\u6674\u5f66  \/p.126<\/p>\n\n\n\n

\u60aa\u6027\u8133\u816b\u760d\u306b\u5bfe\u3057\u3066\u787c\u7d20\u4e2d\u6027\u5b50\u6355\u6349\u7642\u6cd5\u306e\u6709\u52b9\u6027\u306b\u3064\u3044\u3066\/\uff08\u4eac\u90fd\u5927\u5b66\uff09\u9ad8\u57a3\u653f\u96c4\u3001\u7e54\u7530\u7965\u53f2\u3001\u83ca\u6c60\u6674\u5f66\uff08\u4eac\u90fd\u5927\u5b66\u539f\u5b50\u7089\u5b9f\u9a13\u6240\uff09\u5c0f\u91ce\u516c\u4e8c\u3001\u5897\u6c38\u614e\u4e00\u90ce  \/p.127<\/p>\n\n\n\n

\u787c\u7d20\u30b8\u30da\u30d5\u30bf\u30a4\u30c9\u306e\u6bba\u816b\u760d\u52b9\u679c\uff1b\u30dc\u30ed\u30e1\u30c1\u30eb\u30b0\u30ea\u30b7\u30eb\u30d5\u30a7\u30cb\u30eb\u30a2\u30e9\u30cb\u30f3\u3092\u7528\u3044\u305f\u4e2d\u6027\u5b50\u6355\u6349\u7642\u6cd5<\/p>\n\n\n\n

\uff08\u4eac\u90fd\u5927\u5b66\uff09\u9ad8\u57a3\u653f\u96c4\u3001\u5c0f\u91ce\u516c\u4e8c\u3001\u5897\u6c38\u614e\u4e00\u90ce\u3001\u6728\u68a8\u53cb\u5b50\u3001\u53e4\u6797\u5fb9\uff08\u4eac\u90fd\u5927\u5b66\u539f\u5b50\u7089\u5b9f\u9a13\u6240\uff09\u7e54\u7530\u7965\u53f2\u3001\u83ca\u6c60\u6674\u5f66 (Boron Biologicals Inc.) Bernard F. Spielvogel  \/p.142<\/p>\n\n\n\n

Contents<\/strong><\/p>\n\n\n\n

Preface\uff08\u2171\uff09<\/p>\n\n\n\n

Chemical Synthesis of Biologically Active B-10 Carriers and Their Application to BNCT\/ Yoshinori Yamamoto  \/p.1<\/p>\n\n\n\n

Molecular design and synthesis of B-10 carriers for neutron capture therapy\/ Yoshinori Yamamoto  \/p.3<\/p>\n\n\n\n

Synthesis of Carboranes Containing Nucleoside Bases, Unexpectedely High Cytostatic and Cytocidal Toxicity towards Cancer Cells\/ Yoshinori Yamamoto, Toshiya Seko, Hiroyuki Nakamura, Hisao Nemoto, Hiroshi Rojo, Naoto Mukai, Yosiyuki Hashimoto   \/p.7<\/p>\n\n\n\n

Polyols of a Cascade Type as a Water-Solubilizing Element of Carborane Derivatives for Boron Neutron Capture Therapy\/ Hisao Nemoto, J. Gerald Wilson, Hiroyuki Nakamura, Yoshinori Yamamoto  \/p.9<\/p>\n\n\n\n

Molecular design and synthesis of B-10 carriers for neutron capture therapy \/ Yoshinori Yamamoto, Hisao Nemoto, Toshiya Seko, Satoshi Takamatsu, Feng Guang Rong  \/p.10<\/p>\n\n\n\n

Synthesis of Carboranes Containing Nucleoside Bases\/ Yoshinori Yamamoto, Toshiya Seko, Hiroyuki Nakamura, Hisao Nemoto  \/p.14<\/p>\n\n\n\n

A New Water-soluble p-Boronophenylalanine Derivative for Neutron Capture Therapy\/ Hisao Nemoto, Satoshi Iwamoto, Hiroyuki Nakamura, Yoshinori Yamamoto  \/p.20<\/p>\n\n\n\n

Boron-11 NMR of Boron Compounds in the Presence of Cancer Cells\/ Yoshinori Yamamoto, Satoshi Takamatsu, Hiroyuki Nakamura  \/p.24<\/p>\n\n\n\n

Regio-and Stereo-selective Ring Opening of Epoxides with Amide Caprate Reagents\/ Yoshinori Yamamoto, Naoki Asao, Masaki Meguro, Naofumi Tsukada, Hisao Nemoto, Naoki Sadayori, J. Geland Wilson, Hiroyuki Nakamura  \/p.27<\/p>\n\n\n\n

1-Carboranyl-3-(2-methylaziridino)-2-propanol. Synthesis, Selective Uptake by B-16 Melanoma, and Selective Cytotoxicity toward Cancer Cells\/ Yoshinori Yamamoto, Hiroyuki Nakamura  \/p.30<\/p>\n\n\n\n

Basic Study for Development of New Tumor Specific Agents for Neutron Capture Therapy<\/p>\n\n\n\n

Akira Matsumura, Kunio Nakagawa, Yoshihiko Yoshii, Tadao Nose  \/p.33<\/p>\n\n\n\n

Assessment of radiation induced brain damage using 18F-2-deoxy-D-glucose and 99m<\/sup>Tc-hexamethylpropylene amine oxine ( 99m<\/sup>Tc-HM-PAO): A feasible study for positron emission tomography\/ Yoshinao Abe, Hiroshi Fukuda, Shuichi Ono, Jutaro Takahashi, Tachio Sato  \/p.44<\/p>\n\n\n\n

Enhanced Therapeutic Effect on Murine Melanoma and Angiosarcoma Cells by Boron Neutron Capture Therapy Using a Boronated Metalloporphyrin\/ Yoshihiko Yamada, Stephen B. Kahl, Ken-ichi Toda, Masamitsu Ichihashi  \/p.49<\/p>\n\n\n\n

Selective boron accumulation in human ocular melanoma by 10<\/sup>B1<\/sub> -para-boronophenylalanine administration for neutron capture therapy\/ Nobutoshi Wadabayashi, Chihiro Honda, Yutaka Mishima, Masamitsu Ichihashi  \/p.57<\/p>\n\n\n\n

Preclinical studies on gadolinium neutron capture therapy\/ Yasuyuki Akine  \/p. 67<\/p>\n\n\n\n

A Study on the Hyper-Thermal Neutrons for Neutron Capture Therapy\/ Keiji Kanda, Tooru Kobayashi, Yoshinori Sakurai  \/p.79<\/p>\n\n\n\n

Study on the Dose Distribution of the Mixed field with Thermal and Epi-thermal Neutrons for Neutron Capture Therapy\/ Tooru Kobayashi, Yoshinori Sakurai, Keiji Kanda   \/p.81<\/p>\n\n\n\n

The Detection of the Inhomogenous Distribution of 10<\/sup>B-Compounds in Tumors\/ Koji Ono, Shin-ichiro Masunaga, Masao Takagaki, Yuko Kinashi, Mitsuyuki Abe  \/p.87<\/p>\n\n\n\n

Basic and Clinical Researches for the Improvement of Neutron Capture Therapy\/ Haruhiko Kikuchi, Yoshifumi Oda, Masao Takagaki, Shin-ichi Miyatake, Jun A Takahashi, Zhen Hua Zhang   \/p.91<\/p>\n\n\n\n

Gadolinium Neutron Capture Therapy for Brain Tumors -Biological Aspects\/ Masao Takagaki, Yoshifumi Oda, Masato Matsumoto, Haruhiko Kikuchi, Tooru Kobayashi, Keiji Kanda, Yowri Ujeno   \/p.92<\/p>\n\n\n\n

Possibilities Gadorinium Compounds for Neutron Capture Therapy\/ Yoshifumi Oda, Masao Takagaki  \/p.98<\/p>\n\n\n\n

Gadolinium Neutron Capture Therapy for Brain Tumors -in vitro study -\/ Masao Takagaki, Yoshifumi Oda, Haruhiko Kikuchi, Tooru Kobayashi, Keiji Kanda, Yowri Ujeno  \/p.99<\/p>\n\n\n\n

Gadolinium Atom on Neutron Capture Therapy\/ Yoshifumi Oda, Masao Takagaki, Sin-ichi Miyatake, Haruhiko Kikuchi  \/p.101<\/p>\n\n\n\n

Killing Effects of Gadolinium Neutron Capture Reaction on Brain Tumors\/ Masao Takagaki, Yoshifumi Oda, Sin-ichi Miyatake, Haruhiko Kikuchi, Tooru Kobayashi, Keiji Kanda, Yowri Ujeno   \/p.104<\/p>\n\n\n\n

Basic Study of Gadolinium Neutron Capture Therapy for Malignant Brain Tumors\/ Yoshifumi Oda, Masao Takagaki, Shin-ichi Miyatake, Haruhiko Kikuchi  \/p.108<\/p>\n\n\n\n

Basic studies of Neutron Capture Therapy for brain tumor; A new boron compound and its autoradiographic study\/ Masao Takagaki, Yoshifumi Oda, Haruhiko Kikuchi, Syuhei Hayashi, Susumu Harasawa, Kenji Tamura  \/p.114<\/p>\n\n\n\n

Killing Effect of Carboranyl Uridine on Boron Neutron Capture Reaction\/ Masao Takagaki, Yoshifumi Oda, Zhen Hua Zhang, Haruhiko Kikuchi, Hiroyuki Nakamura, Hisao Nemoto, Toshiya Seko, Yoshinori Yamamoto, Albert H. Soloway, Tooru Kobayashi, Keiji Kanda   \/p.116<\/p>\n\n\n\n

Chemotherapy using DDS in Malignant Brain Tumors\/ Yoshifumi Oda, Jun Takahashi, Masao Takagaki, Kenji Ohyama, Shin-ichi Miyatake, Haruhiko Kikuchi  \/p.119<\/p>\n\n\n\n

Early Clinical Experience of Boron Neutron Capture Therapy for Glioblastoma Patients\/ Yoshifumi Oda, Masao Takagaki, Zhen Hua Zhang, Shoji Nakatsu, Shin-ichi Miyatake, Satoshi Nakao, Haruhiko Kikuchi  \/p.126<\/p>\n\n\n\n

Is BSH Effective or not on BNCT for Malignant Brain Tumors? \/ Masao Takagaki, Yoshifumi Oda, Haruhiko Kikuchi, Koji Ono, Shinichiro Masunaga  \/p.127 Tumor Cell Killing Effect of Boronated Dipeptide; Boromethylglycylphenylalanine on Boron Neutron Capture Therapy for Malignant Brain Tumors\/ Masao Takagaki, Koji Ono, Shinichiro Masunaga, Yuko Kinashi, Tooru Kobayashi, Yoshifumi Oda, Haruhiko Kikuchi, Bernard F. Spielvogel  \/p.142<\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

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