{"id":4689,"date":"2026-06-01T13:52:35","date_gmt":"2026-06-01T04:52:35","guid":{"rendered":"https:\/\/adm.rri.kyoto-u.ac.jp\/pub\/?p=4689"},"modified":"2026-06-01T13:52:35","modified_gmt":"2026-06-01T04:52:35","slug":"kurri-tr-404","status":"publish","type":"post","link":"https:\/\/adm.rri.kyoto-u.ac.jp\/pub\/kurri-tr-404\/","title":{"rendered":"KURRI-TR-404"},"content":{"rendered":"\n
\"\"<\/figure>\n\n\n\n

\u8ee2\u79fb\u6027\u306a\u3089\u3073\u306b\u6df1\u9054\u6027\u30d2\u30c8\u60aa\u6027\u9ed2\u8272\u816b\u306e\u9078\u629e\u7684\u71b1\u4e2d\u6027\u5b50\u6355\u6349\u7642\u6cd5\u306e\u6a39\u7acb
Further Development of Thermal Neutron Capture Therapy for Metastatic and Deeply-Invasive Human Malignant Melanoma<\/p>\n\n\n\n

1995\u5e743\u6708\u3000(March, 1995)
\u7de8\u96c6\uff1a\u4e09\u5cf6\u8c4a
Edited by\uff1aYutaka Mishima<\/p>\n\n\n\n

\u76ee\u6b21<\/strong> \/ Contents<\/p>\n\n\n\n

    \n
  1. Selective Thermal Neutron Capture Therapy of Cancer Cells Using their Specific Metabolic Activities-Melanoma as Prototype\/ Yutaka Mishima\u00a0 \/p.1<\/li>\n\n\n\n
  2. Boron Analytical Studies on 10<\/sup>B1<\/sub>-BPA Administration for Neutron Capture Therapy of Malignant Melanoma\/ Chihiro Honda, Nobutoshi Wadabayashi, Kazuo Yoshino, Junichi Hiratsuka, Hiroshi Karashima, Tooru Kobayashi, Hiroshi Fukuda, Masamitsu Ichihashi and Yutaka Mishima\u00a0 \/p.21<\/li>\n\n\n\n
  3. 10<\/sup>B1<\/sub>-BPA Administration to Melanoma Patients for Neutron Capture Therapy (II)-from Nov.,1991 to Dec.,1994-\/ Chihiro Honda, Nobutoshi Wadabayashi, Masamitsu Ichihashi, Yutaka Mishima, Kazuo Yoshino, Junichi Hiratsuka, Hiroshi Karashima, Hiroshi Fukuda and Tooru Kobayashi\u00a0 \/p.26<\/li>\n\n\n\n
  4. Two Cases of Primary Malignant Melanoma Treated by Selective Melanoma Thermal Neutron Capture Therapy \/ Kazumi Watanabe, Kaoru Ito, Yasuyuki Kaneko, Sumiko Satake, Satoshi Yamada, Hideo Yamaguchi, Tatsuya Takenouchi, Masaaki Ito and Yutaka Mishima\u00a0 \/p.31<\/li>\n\n\n\n
  5. Selective Boron Accumulation in Human Ocular Melanoma vs Surrounding Eye Components after 10<\/sup>B1<\/sub>-p-Boronophenylalanine Administration. Prerequisite for Clinical Trial of Neutron-Capture Therapy\/ Nobutoshi Wadabayashi, Chihiro Honda, Yutaka Mishima and Masamitsu Ichihashi\u00a0 \/p.37<\/li>\n\n\n\n
  6. Selective Detection of Brain Metastasis of Malignant Melanoma Using 18<\/sup>F-10<\/sup>B-L-Boronophenylalanine with Positron Emission Tomography\/ Kazumasa Ehara, Norihiko Tamaki, Yoshie Hara, Yoshie Imahori, Hitoshi Horii, Satoshi Ueda, Junichi Hiratsuka and Yutaka Mishima\u00a0 \/p.43<\/li>\n\n\n\n
  7. Enhanced therapeutic Effect on Morine Melanoma and Angiosarcoma Cells by Boron Neutron Capture Therapy Using a Boronated Metalloporphyrin\/ Yoshihiko Yamada, Ken-ichi Toda, Stephen B. Kahl and Masamitsu Ichihashi\u00a0 \/p.47<\/li>\n\n\n\n
  8. Physics of Boron Neutron Capture Therapy in Japan\/ Keiji Kanda\u00a0 \/p.60<\/li>\n\n\n\n
  9. KUR\u91cd\u6c34\u8a2d\u5099\u306e\u7279\u5fb4\u3068\u305d\u306e\u5229\u7528\u6cd5\/ \u795e\u7530\u5553\u6cbb
    Characteristics of KUR Heavy Water Facility and Its Application\/ Keiji Kanda\u00a0\u00a0 \/p.68<\/li>\n\n\n\n
  10. \u91cd\u6c34\u71b1\u4e2d\u6027\u5b50\u8a2d\u5099\u6539\u9020\u306e\u6982\u5ff5\u8a2d\u8a08\u691c\u8a0e\/ \u53e4\u6797\u5fb9\u3001\u795e\u7530\u5553\u6cbb\u3001\u85e4\u7530\u85ab\u9855\u3001\u5c0f\u91ce\u516c\u4e8c
    Conceptional Study on Remodeling of the Heavy Water Facility of the Kyoto University Reactor\/ Tooru Kobayashi, Keiji Kanda, Yoshiaki Fujita and Koji Ono\u00a0 \/p.72<\/li>\n\n\n\n
  11. KUR\u91cd\u6c34\u71b1\u4e2d\u6027\u5b50\u8a2d\u5099\u6539\u9020\u306e\u539f\u5b50\u7089\u5de5\u5b66\u9762\u304b\u3089\u306e\u6700\u9069\u5316\u8a2d\u8a08\u691c\u8a0e\/ \u53e4\u6797\u5fb9\u3001\u685c\u4e95\u826f\u61b2\u3001\u795e\u7530\u5553\u6cbb\u3001\u85e4\u7530\u85ab\u9855
    A Design Study on the Remodeling of KUR-D2<\/sub>O Thermal Neutron Facility for the Optimization from Reactor Physics and Engineerings \/ Tooru Kobayashi, Yoshinori Sakurai, Keiji Kanda and Yoshiaki Fujita\u00a0 \/p.81<\/li>\n\n\n\n
  12. The Utilization of Hyper-Thermal Neutrons for Neutron Capture\u00b7Therapy\/ Yoshinori Sakurai, Tooru Kobayashi and Keiji Kanda\u00a0 \/p.89<\/li>\n\n\n\n
  13. \u30cf\u30a4\u30d0\u30fc\u71b1\u4e2d\u6027\u5b50\u7167\u5c04\u5834\u306e\u8a2d\u8a08\u691c\u8a0e\/ \u685c\u4e95\u826f\u61b2\uff0e\u53e4\u6797\u5fb9\uff0c\u795e\u7530\u5553\u6cbb
    A Feasibility Study on the Hyper-Thermal Neutron Irradiation Field for Neutron Capture Therapy\/ Yoshinori Sakurai, Tooru Kobayashi and Keiji Kanda\u00a0 \/p.89<\/li>\n\n\n\n
  14. \u4e2d\u6027\u5b50\u30a8\u30cd\u30eb\u30ae\u30fc\u30b9\u30da\u30af\u30c8\u30eb\u30b7\u30d5\u30bf\u30fc\u306e\u8a2d\u8a08\u691c\u8a0e\/ \u685c\u4e95\u826f\u61b2\uff0c \u53e4\u6797\u5fb9\uff0c \u795e\u7530\u5553\u6cbb\uff0c \u85e4\u7530\u85ab\u9855
    A Study on the Design of the Neutron Energy Spectrum Shifter\/ Yoshinori Sakurai, Tooru Kobayashi, Keiji Kanda and Yoshiaki Fujita\u00a0 \/p.106<\/li>\n\n\n\n
  15. A Fundamental Study on Hyper-Thermal Neutrons for Neutron Capture therapy\/ Yoshinori Sakurai, Tooru Kobayashi and Keiji Kanda\u00a0 \/p.115<\/li>\n\n\n\n
  16. Hyper-Thermal Neutron Irradiation Field for Neutron Capture therapy\/ Yoshinori Sakurai, Tooru Kobayashi and Keiji Kanda\u00a0 \/p.126<\/li>\n\n\n\n
  17. Feasibility Study on Neutron Energy Spectrum Shifter in the KUR Heavy Water Facility for Neutron Capture therapy \/ Yoshinori Sakurai, Tooru Kobayashi, Keiji Kanda and Yoshiaki Fujita\u00a0 \/p.134<\/li>\n\n\n\n
  18. Design Study on Triangular-Hexagonal TRIGA Core for Epithermal Neutron Irradiation \/ Otohiko Aizawa\u00a0 \/p.152<\/li>\n\n\n\n
  19. Chemical Modeling for Boron Accumulation to and Release from Melanoma \/ Kazuo Yoshino, Yoshihiro Mori, Hidetake Kakihana, Hiroaki Takahashi, Yutaka Mishima and Masamitsu Ichihashi\u00a0 \/p.158<\/li>\n\n\n\n
  20. Chemical Properties of p-, m-, o-<\/em>Boronophenylalanine \/ Kazuo Yoshino, Nobuya Watanabe, Hiroaki Takahashi, Shinji Watanabe, Yoshihiro Mori, Masamitsu Ichihashi, Hidetake Kakihana and Yutaka Mishima\u00a0 \/p.165<\/li>\n\n\n\n
  21. Examination of Stability of p-, m-, o-<\/em>Boronophenylalanine in Blood with High Performance Liquid Chromatography\/ Kazuo Yoshino, Naoko Koike, Yuko Kuroda, Yoshihiro Mori, Masamitsu Ichihashi, Hidetake Kakihana and Yutaka Mishima\u00a0 \/p.171<\/li>\n\n\n\n
  22. p-\u30dc\u30ed\u30ce\u30d5\u30a7\u30cb\u30eb\u30a2\u30e9\u30cb\u30f3\u3068\u30e1\u30e9\u30cb\u30f3\u4ee3\u8b1d\u524d\u99c6\u4f53L\u30fc\u30c9\u30fc\u30d1\u3068\u306e\u932f\u5f62\u6210\u304a\u3088\u3073\u540c\u932f\u4f53\u306e\u9178\u5316\u53cd\u5fdc\uff0dp-\u30dc\u30ed\u30ce\u30d5\u30a7\u30cb\u30eb\u30a2\u30e9\u30cb\u30f3\u306b\u3088\u308b\u60aa\u6027\u9ed2\u8272\u816b\u3078\u306e10<\/sup>B\u306e\u96c6\u7a4d\u3001\u6e1b\u8870\u6a5f\u69cb\u306e\u5316\u5b66\u7684\u8003\u5bdf\u4e00\/ \u5409\u91ce\u548c\u592b\u3001\u9ad8\u6a4b\u5b8f\u660e\u3001\u9ce5\u5c45\u6210\u5e78\u3001\u68ee\u82b3\u5f18\u3001\u57a3\u82b1\u79c0\u6b66
    Complex Formation of p-Boronophenylalanine with L-DOPA (a Precursor of Melanine Metabolism) and Oxidation Reaction of the Analogs \/ Kazuo Yoshino, Hiroaki Takahasi, Naruyuki Torii, Yoshihiro Mori and Hidetake Kakihana\u00a0 \/p.177<\/li>\n\n\n\n
  23. 0\u2014\u304a\u3088\u3073m\u2014\u30dd\u30ed\u30ce\u30d5\u30a7\u30cb\u30eb\u30a2\u30e9\u30cb\u30f3\u306e\u5408\u6210\u3068\u5149\u5b66\u5206\u5272\/\u9ad8\u6a4b\u5b8f\u660e\uff0c\u5409\u91ce\u548c\u592b\uff0c\u4e38\u5c71\u8cac\u4fe1\uff0c\u68ee\u82b3\u5f18
    Synthesis of o-and m-Boronophenylalanine and their Optical Resolution\/ Hiroaki Takahasi, Kazuo Yoshino, Takanobu Maruyama and Yoshihiro Mori\u00a0 \/p.184<\/li>\n\n\n\n
  24. Netropsin and Distamycin Analogues Bearing Ortho-Carborane \/ Yoshinori Yamamoto, Jianping Cai, Hiroyuki Nakamura, Naoki Sadayori and Hisao Nemoto\u00a0 \/p.188<\/li>\n\n\n\n
  25. Synthesis of a Water-Soluble o-Carborane Bearing Uracil Moiety via Palladium Catalyzed Reaction under Essentially Neutral Conditions\/ Hisao Nemoto, Jianping Cai and Yoshinori Yamamoto\u00a0 \/p.194<\/li>\n\n\n\n
  26. BNCT of Malignant Melanoma-Radiobiological Analysis and Data Comparison with Conventional Radiotherapy\/ Hiroshi Fukuda, Yutaka Mishima, Junichi Hiratsuka, Chihiro Honda, Nobutoshi Wadabayashi, Tooru Kobayashi, Kazuo Yoshino, Hiroshi Karashima, Jutaro Takahashi, Yoshinao Abe, Keiji Kanda and Masamitsu Ichihashi\u00a0\u00a0 \/p.197<\/li>\n\n\n\n
  27. Pharmacokinetics of 10<\/sup>B-BPA in the Tumor, Skin and Blood in Melanoma Patients-A Study for Boron Neutron Capture Therapy of Malignant Melanoma\/ Hiroshi Fukuda, Chihiro Honda, Nobutoshi Wadabayashi, Tooru Kobayashi, Kazuo Yoshino, Junichi Hiratsuka, Jutaro Takahashi, Masamitsu Ichihashi and Yutaka Mishima\u00a0 \/p.204<\/li>\n\n\n\n
  28. Early Clinical Trial and Related Research for the Development of BNCT \/ Hiroshi Fukuda and Yutaka Mishima\u00a0 \/p.210<\/li>\n\n\n\n
  29. Boron Neutron Capture Therapy of Malignant Melanoma Using 10<\/sup>B-Paraboronophenylalanine with Special Reference to Evaluation of Radiation Dose and Damage to the Normal Skin \/ Hiroshi Fukuda, Junichi Hiratsuka, Chihiro Honda, Tooru Kobayashi, Kazuo Yoshino, Hiroshi Karashima, Jutaro Takahashi, Yoshinao Abe, Keiji Kanda, Masamitsu Ichihashi and Yutaka Mishima\u00a0 \/p.215<\/li>\n\n\n\n
  30. RBE of BNCT for Human Skin-Re-Evaluation Based on Ten Cases of Human Melanoma BNCT\/ Junichi Hiratsuka, Hiroshi Fukuda, Tooru Kobayashi, Hiroshi Karashima, Kazuo Yoshino, Chihiro Honda, Nobutoshi Wadabayashi and Yutaka Mishima\u00a0 \/p.223<\/li>\n\n\n\n
  31. \u7d50\u7bc0\u578b\u30e1\u30e9\u30ce\u30fc\u30de\u306e\u71b1\u4e2d\u6027\u5b50\u7dda\u91cf\u5206\u5e03\u4e00\u52d5\u7269\u3092\u7528\u3044\u305f\u524d\u81e8\u5e8a\u8a66\u9a13\u3068\u30d2\u30c8\u81e8\u5e8a\u30c7\u30fc\u30bf\u306e\u89e3\u6790\u4e00\/ \u5e73\u585a\u7d14\u4e00\u3001\u8f9b\u5d8b\u535a\u3001\u798f\u7530\u5bdb\u3001\u672c\u7530\u5343\u535a\u3001\u548c\u7530\u6797\u5c55\u5e74\u3001 \u53e4\u6797\u5fb9\u3001\u795e\u7530\u5553\u6cbb\u3001\u4e09\u5d8b\u8c4a
    Thermal Neutron Distribution in Nodular Melanoma for BNCT-Data Analysis of Pre-Clinical Study and Clinical Trial\u2015
    Junichi Hiratsuka, Hiroshi Karashima, Hiroshi Fukuda, Chihiro Honda, Nobutoshi Wadabayashi, Tooru Kobayashi, Keiji Kanda and Yutaka Mishima\u00a0 \/p.227<\/li>\n\n\n\n
  32. A Basic Concept for PET-BNCT System \/ Yoshio Imahori, Satoshi Ueda, Yoshio Ohmori, Eiji Yoshino, Koji Ono, Tooru Kobayashi, Tatsuo Ido and Yutaka Mishima\u00a0 \/p.233<\/li>\n\n\n\n
  33. Positron Emission Tomography and Boron Neutron Capture Therapy System to the Patient with Malignant Brain Tumor
    -The First Clinical Trial Using 10<\/sup>B-BPA\/ Satoshi Ueda, Yoshio Imahori, Yoshio Ohmori, Eiji Yoshino, Koji Ono, Tooru Kobayashi, Masao Takagaki, Yoshifumi Oda, Tatsuo Ido and Yutaka Mishima\u00a0 \/p.240<\/li>\n\n\n\n
  34. Assessment of Photon Contributions in Gadolinium Neutron\/ Capture Reactions-A Preliminary Study\u2014\/ Koichi Tokuuye, Nobuhiko Tokita, Yasuyuki Akine, Tooru Kobayashi, and Keiji Kanda\u00a0 \/p.246<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    \u8ee2\u79fb\u6027\u306a\u3089\u3073\u306b\u6df1\u9054\u6027\u30d2\u30c8\u60aa\u6027\u9ed2\u8272\u816b\u306e\u9078\u629e\u7684\u71b1\u4e2d\u6027\u5b50\u6355\u6349\u7642\u6cd5\u306e\u6a39\u7acbFurther Development of Thermal Neutron Capture Therapy for Metastatic and Deep […]<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"12","format":"standard","meta":{"_uag_custom_page_level_css":"","_locale":"ja","_original_post":"https:\/\/adm.rri.kyoto-u.ac.jp\/pub\/?p=4689","footnotes":""},"categories":[17],"tags":[],"class_list":["post-4689","post","type-post","status-publish","format-standard","hentry","category-technical-repprt","ja"],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"nakatani","author_link":"https:\/\/adm.rri.kyoto-u.ac.jp\/pub\/author\/nakatani\/"},"uagb_comment_info":0,"uagb_excerpt":"\u8ee2\u79fb\u6027\u306a\u3089\u3073\u306b\u6df1\u9054\u6027\u30d2\u30c8\u60aa\u6027\u9ed2\u8272\u816b\u306e\u9078\u629e\u7684\u71b1\u4e2d\u6027\u5b50\u6355\u6349\u7642\u6cd5\u306e\u6a39\u7acbFurther Development of …","_links":{"self":[{"href":"https:\/\/adm.rri.kyoto-u.ac.jp\/pub\/wp-json\/wp\/v2\/posts\/4689","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/adm.rri.kyoto-u.ac.jp\/pub\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/adm.rri.kyoto-u.ac.jp\/pub\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/adm.rri.kyoto-u.ac.jp\/pub\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/adm.rri.kyoto-u.ac.jp\/pub\/wp-json\/wp\/v2\/comments?post=4689"}],"version-history":[{"count":2,"href":"https:\/\/adm.rri.kyoto-u.ac.jp\/pub\/wp-json\/wp\/v2\/posts\/4689\/revisions"}],"predecessor-version":[{"id":5141,"href":"https:\/\/adm.rri.kyoto-u.ac.jp\/pub\/wp-json\/wp\/v2\/posts\/4689\/revisions\/5141"}],"wp:attachment":[{"href":"https:\/\/adm.rri.kyoto-u.ac.jp\/pub\/wp-json\/wp\/v2\/media?parent=4689"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/adm.rri.kyoto-u.ac.jp\/pub\/wp-json\/wp\/v2\/categories?post=4689"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/adm.rri.kyoto-u.ac.jp\/pub\/wp-json\/wp\/v2\/tags?post=4689"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}