{"id":4720,"date":"2026-06-01T15:40:35","date_gmt":"2026-06-01T06:40:35","guid":{"rendered":"https:\/\/adm.rri.kyoto-u.ac.jp\/pub\/?p=4720"},"modified":"2026-06-01T15:40:35","modified_gmt":"2026-06-01T06:40:35","slug":"kurri-tr-427","status":"publish","type":"post","link":"https:\/\/adm.rri.kyoto-u.ac.jp\/pub\/kurri-tr-427\/","title":{"rendered":"KURRI-TR-427"},"content":{"rendered":"\n
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\u907a\u4f1d\u5b50\u5c0e\u5165\u306b\u3088\u308b\u304c\u3093\u71b1\u4e2d\u6027\u5b50\u6355\u6349\u7642\u6cd5\u306e\u9069\u5fdc\u62e1\u5927
Gene Transfer-applied Cancer Boron Neutron Capture Therapy<\/p>\n\n\n\n

1999\u5e742\u6708\u3000(February, 1999)
\u7de8\u96c6\uff1a\u4e09\u5cf6\u8c4a
Edited by\uff1aYutaka Mishima<\/p>\n\n\n\n

\u76ee\u6b21<\/strong>\/Contents<\/strong><\/p>\n\n\n\n

\u2160. \u672c\u7814\u7a76\u306e\u76ee\u7684\u3068\u7814\u7a76\u306e\u73fe\u6cc1\uff08\u2177\uff09<\/p>\n\n\n\n

\u2161. \u7814\u7a76\u767a\u8868<\/p>\n\n\n\n

    \n
  1. Current Clinical Paradigms in Melanoma BNCT-Leading to Cell Modulation Era Teamed with Passive and Active 10B-Biodelivery Systems\/ Yutaka Mishima, Hirofumi Kondoh, Kazuo Yoshino and Junichi Hiratsuka\u00a0 \/p.1<\/li>\n\n\n\n
  2. Enhanced Melanogenesis Induced by Tyrosinase Gene-Transfer Increases Boron-Uptake and Killing Effect of Boron Neutron Capture Therapy for Amelanotic Melanoma \/ Tatsuya Tsuboi, Hirofumi Kondoh, Junichi Hiratsuka and Yutaka Mishima\u00a0 \/p.18<\/li>\n\n\n\n
  3. Melanoma and Nonmelanoma Neutron Capture Therapy Using Gene Therapy-Overview\/ Yutaka Mishima\u00a0 \/p.26<\/li>\n\n\n\n
  4. In vivo Diagnosis of Human Malignant Melanoma with Positron Emission Tomography Using Specific Melanoma-seeking 18<\/sup>F-DOPA Analogue \/ Yutaka Mishima, Yoshio Imahori, Chihiro Honda, Junichi Hiratsuka, Satoshi Ueda. and Tatsuo Ido\u00a0 \/p.42<\/li>\n\n\n\n
  5. Neutron Capture Therapy Using 10<\/sup>B-BPA and Gd-DTPA in Combination for Hamster Melanoma\/ Chihiro Honda, Yutaka Mishima, Junichi Hiratsuka, Nobutoshi Wadabayashi, Hiroshi Karashima and Masamitsu Ichihashi\u00a0 \/p.49<\/li>\n\n\n\n
  6. Pharmacokinetics of 10<\/sup>B-p-boronophenylalaninein Tumours, Skin and Blood of Melanoma Patients-A Study of Boron Neutron Capture Therapy for Malignant Melanoma \/ Hiroshi Fukuda, Chihiro Honda, Nobutoshi Wadabayashi, Tooru Kobayashi, Kazuo Yoshino, Junichi Hiratsuka, Jutaro Takahashi, Takashi Akaizawa, Yoshinao Abe, Masamitsu Ichihashi and Yutaka Mishima\u00a0 \/p.53<\/li>\n\n\n\n
  7. \u30de\u30a6\u30b9melanoma\u8133\u5185\u79fb\u690d\u30e2\u30c7\u30eb\u306b\u304a\u3051\u308b10<\/sup>B-boronophenylalanine \u306e\u816b\u760d\u96c6\u7a4d\u6027 \/\u7a40\u5185\u9686\uff0c\u7389\u6728\u7d00\u5f66\uff0c\u4eca\u5800\u826f\u592b\uff0c\u576a\u4e95\u9054\u4e5f\uff0c\u8fd1\u85e4\u6d69\u6587\uff0c\u4e09\u5d8b\u8c4a
    Accumulation of 10<\/sup>B-boronophenylalanine in Intracerebral Implantation Model of Mouse Melanoma Cells \/ Takashi Kokunai, Norihiko Tamaki, Yoshio Imahori, Tatsuya Tsuboi, Hirofumi Kondoh and Yutaka Mishima\u00a0 \/p.75<\/li>\n\n\n\n
  8. A Novel Approach for in vivo Gene Delivery to Tumor Cells via Transferrin Receptor by Transferrin-Strepavidin-DNA Conjugate \/ Yasushi Sato-, Hiroshi Neda, Katunori Sasaki, Minoru Takahashi, Junki Fukaura, Shigeyuki Fujii, Yoshikazu Koshita, Naofumi Yamauchi, Junji Kato, Sumio Sakamaki and Yoshiro Niitsu\u00a0 \/p.81<\/li>\n\n\n\n
  9. A Big Gene Linked to Small Eyes Encodes Multiple Mitf Isoforms – Many Promoters Make Light Work\/ Ken-ichi Yasumoto, Shintaro Amae, Tetsuo Udono, Nobuo Fuse, Kazuhisa Takeda and Shigeki Shibahara\u00a0 \/p.97<\/li>\n\n\n\n
  10. Role of Neurofibromin in Modulation of Expression of the Tyrosinase-related Protein 2 Gene\/ Hiroyuki Suzuki, Kazuhiro Takahashi, Ken-ichi Yasumoto, Shintaro Amae, Miki Yoshizawa., Nobuo Fuse and Shigeki Shibahara\u00a0 \/p.105<\/li>\n\n\n\n
  11. Identification of a Novel Isoform of Microphthalmia-associated Transcription Factor That Is Enriched in Retinal Pigment Epithelium\/ Shintaro Amae, Nobuo Fuse, Ken-ichi Yasumoto, Shigeru Sato, Ichiro Yaji.ma, Hiroaki Yamamoto, Tetsuo Udono, Yusuf K. Durlu, Makoto Tamai, Kazuhiro Takahashi and Shigeki Shibahara\u00a0 \/p.112<\/li>\n\n\n\n
  12. A Further Mechanism Study of Boron Accumulation to and Release from Melanoma with p-Boronophenylalanine \/ Kazuo Yoshino, Mamiko Kamijo, Mototetsu Kimura, Yutaka Mishima, Hirofumi Kondoh, Mitsutaka Kadota, Shusuke Ito, Kazumasa Wakamatsu and Hidetake Kakihana\u00a0 \/p.118<\/li>\n\n\n\n
  13. Capture of p<\/em>-Boronophenylalanine in Malignant Melanoma Cells by Complex Formation with Melanin Monomers, DOPA, DBI and DHICA \/ Kazuo Yoshino, Yutaka Mishima, Mototetsu Kimura, Junichi Hiratsuka, Yoshihiro Mori, Shosuke Ito and Hidetake Kakihana\u00a0 \/p.124<\/li>\n\n\n\n
  14. Determination of Released Boric Acid in vivo after p-Boronophenylalanine Administration into Melanoma-bearing Subjects \/ Kazuo Yoshino, Ryoko Nakajima, Akira Takaoka, Yoshihiro Mori, Hidetake Kakihana, Yutaka Mishima and Masamitsu Ichihashi\u00a0 \/p.129<\/li>\n\n\n\n
  15. \u30e1\u30e9\u30ce\u30fc\u30de\u30d8\u306e10<\/sup>B\u53d6\u8fbc\u6a5f\u69cb\u4e0010<\/sup>B-p-\u30dc\u30ed\u30ce\u30d5\u30a7\u30cb\u30eb\u30a2\u30e9\u30cb\u30f3\u306b\u3088\u308b10<\/sup>B\u306e\u30e1\u30e9\u30ce\u30fc\u30de\u7d30\u80de\u3078\u306e\u53d6\u308a\u8fbc\u307f\u3068\u305d\u306e\u96c6\u7a4d\u6a5f\u69cb \/\u5409\u91ce\u548c\u592b\u3001\u4e09\u5d8b\u8c4a\u3001\u6728\u6751\u57fa\u54f2\u3001\u4f0a\u85e4\u7965\u8f14\u3001\u672c\u7530\u5343\u535a
    Mechanism Study on10<\/sup>B-Accumulationin Melanoma Cells by 10<\/sup>B-p-Boronophenylalanine \/ Kazuo Yoshino, Yutaka Mishima, Mototetsu Kimura, Shosuke Ito and Chihiro Honda\u00a0 \/p.134<\/li>\n\n\n\n
  16. Selective Uptake of p-Boronophenylalanine Increases by Transfecting Tyrosinase Gene to Melanoma Cells \/ Junichi Hiratsuka, Hirofumi Kondoh, Tatsuya Tsuboi, Kazuo Yoshino, Yoshinari Imajo and Yutaka Mishima\u00a0\u00a0 \/p.138<\/li>\n\n\n\n
  17. Tumor-killing Effect of BNCT after Administration of o-, m-and p-Boronophenylalanine \/ Junichi Hiratsuka, Kazuo Yoshino, Chihiro Honda, Yutaka Mishima and Masamitsu Ichihashi\u00a0 \/p.148<\/li>\n\n\n\n
  18. The Combined Effect of Boronophenylalanine and Borocaptate in Boron Neutron Capture Therapy for SCCVII Tumors in Mice \/ Koji Ono, Shin-ichiro Masunaga, Minoru Suzuki, Yuko Kinashi, Masao Takagaki and Mitsuhiko Akaboshi\u00a0 \/p.152<\/li>\n\n\n\n
  19. Effects of Electroporation on the Cell Killing by Boron Neutron Capture Therapy Using Borocaptate Sodium (10<\/sup>B-BSH) \/Koji Ono, Yuko Kinashi, Shin-ichiro Masunaga, Minoru Suzuki and Masao Takagaki\u00a0 \/p.163<\/li>\n\n\n\n
  20. Boron Neutron Capture Therapy for Malignant Glioma at Kyoto\/ University Reactor \/ Koji Ono, Satoshi Ueda, Yoshifumi Oda, Yoshinobu Nakagawa, Shinich Miyatake, Masao Takagaki, Masami Osawa and Tooru Kobayashi\u00a0 \/p.169<\/li>\n\n\n\n
  21. \u65b0\u898f\u306e\u30a8\u30de\u30eb\u30b8\u30e7\u30f3\u6db2\u6ef4\u878d\u5408\u6cd5\u306b\u3088\u308b\u4e2d\u6027\u5b50\u6355\u6349\u7642\u6cd5\u7528\u30ad\u30c8\u30b5\u30f3\u30ca\u30ce\u30d1\u30fc\u30c6\u30a3\u30af\u30eb\u306e\u8abf\u88fd\u3068\u305d\u306e\u8a55\u4fa1\/ \u5fb3\u6e80\u5b8f\u4e4b\u3001\u5e02\u5ddd\u79c0\u559c\u3001\u798f\u68ee\u7fa9\u4fe1\u3001\u5e73\u585a\u7d14\u4e00\u3001\u6afb\u4e95\u826f\u61b2\u3001\u53e4\u6797\u5fb9\u00a0
    Preparation and Evaluation of Chitosan Nanoparticles for Neutron-Capture Therapy by a Novel Emulsion-Droplet Coalescence Technique \/ Hiroyuki Tokumitsu, Hideki Ichikawa, Yoshinobu Fukumori, Junichi Hiratsuka, Yoshinori Sakurai and Tooru Kobayashi\u00a0 \/p.176<\/li>\n\n\n\n
  22. \u30ec\u30b7\u30c1\u30f3\u304a\u3088\u3073\u30b3\u30fc\u30b5\u30fc\u30d5\u30a1\u30af\u30bf\u30f3\u30c8\u3067\u5b89\u5b9a\u5316\u3057\u305f\u4e2d\u6027\u5b50\u6355\u6349\u7642\u6cd5\u7528\u30a8\u30de\u30eb\u30b7\u30e7\u30f3\u306e\u4f53\u5185\u52d5\u614b\/ \u5e73\u91ce\u85ab\uff0c\u5bae\u672c\u96c5\u4ec1\u3001\u5e02\u5ddd\u79c0\u559c\u3001\u798f\u68ee\u7fa9\u4fe1
    Biodistribution of Emulsions Stabilized with Phosphatidylcholine-Surfactant Mixtures for Neutron-Capture Therapy \/ Kaoru Hirano, Masahito Miyamoto, Hideki Ichikawa and Yoshinobu Fukumori\u00a0 \/p.184<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    \u907a\u4f1d\u5b50\u5c0e\u5165\u306b\u3088\u308b\u304c\u3093\u71b1\u4e2d\u6027\u5b50\u6355\u6349\u7642\u6cd5\u306e\u9069\u5fdc\u62e1\u5927Gene Transfer-applied Cancer Boron Neutron Capture Therapy 1999\u5e742\u6708\u3000(February, 1999)\u7de8\u96c6\uff1a\u4e09 […]<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"12","format":"standard","meta":{"_uag_custom_page_level_css":"","_locale":"ja","_original_post":"https:\/\/adm.rri.kyoto-u.ac.jp\/pub\/?p=4720","footnotes":""},"categories":[17],"tags":[],"class_list":["post-4720","post","type-post","status-publish","format-standard","hentry","category-technical-repprt","ja"],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"nakatani","author_link":"https:\/\/adm.rri.kyoto-u.ac.jp\/pub\/author\/nakatani\/"},"uagb_comment_info":0,"uagb_excerpt":"\u907a\u4f1d\u5b50\u5c0e\u5165\u306b\u3088\u308b\u304c\u3093\u71b1\u4e2d\u6027\u5b50\u6355\u6349\u7642\u6cd5\u306e\u9069\u5fdc\u62e1\u5927Gene Transfer-applied Cancer Bor…","_links":{"self":[{"href":"https:\/\/adm.rri.kyoto-u.ac.jp\/pub\/wp-json\/wp\/v2\/posts\/4720","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/adm.rri.kyoto-u.ac.jp\/pub\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/adm.rri.kyoto-u.ac.jp\/pub\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/adm.rri.kyoto-u.ac.jp\/pub\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/adm.rri.kyoto-u.ac.jp\/pub\/wp-json\/wp\/v2\/comments?post=4720"}],"version-history":[{"count":2,"href":"https:\/\/adm.rri.kyoto-u.ac.jp\/pub\/wp-json\/wp\/v2\/posts\/4720\/revisions"}],"predecessor-version":[{"id":5165,"href":"https:\/\/adm.rri.kyoto-u.ac.jp\/pub\/wp-json\/wp\/v2\/posts\/4720\/revisions\/5165"}],"wp:attachment":[{"href":"https:\/\/adm.rri.kyoto-u.ac.jp\/pub\/wp-json\/wp\/v2\/media?parent=4720"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/adm.rri.kyoto-u.ac.jp\/pub\/wp-json\/wp\/v2\/categories?post=4720"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/adm.rri.kyoto-u.ac.jp\/pub\/wp-json\/wp\/v2\/tags?post=4720"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}